Relationship between Serum HIF-1α,ChREBP and Glucose and Lipid Metabolism,Renal Function in Patients with Type 2 Diabetic Kidney Disease and its Diagnostic Value
Objective:To investigate the relationship between serum hypoxia inducible factor-1α(HIF-1α),carbohydrate response element binding protein(ChREBP)and glucose and lipid metabolism,renal function in patients with type 2 diabetic kidney disease(T2DKD)and its diagnostic value.Methods:100 patients with T2DKD who were admitted to our hospital from January 2021 to January 2022 were selected as T2DKD group,100 patients with simple T2DM during the same period were selected as T2DM group,and 100 healthy people in our hospital during the same period were selected as control group.Serum HIF-1α,ChREBP and glucose and lipid metabolism indexes[fasting blood glucose(FBG),postprandial 2hFBG(2hFBG),hemoglobin A1c(HbA1c),homeostasis model assess-ment-insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)],renal function indexes[urinary albumin/creatinine ratio(UACR),estimated glomerular filtra-tion rate(eGFR)]were detected.The correlation between serum HIF-1α and ChREBP levels and glycolipid metabolism and renal func-tion indexes in T2DKD patients were analyzed by pearson correlation analysis,the diagnostic value of serum HIF-1α and ChREBP levels in T2DKD were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum HIF-1α,ChREBP,FBG,2hFBG,HbA1c,HOMA-IR,TC,TG,LDL-C and UACR in control group,T2DM group and T2DKD group increased in turn,while HDL-C and eGFR decreased in turn(P＜0.05).Pearson correlation analysis showed that,serum HIF-1α and ChREBP levels in T2DKD patients were positively correlated with FBG,HbA1 c,HOMA-IR,TC,TG,LDL-C and UACR,and negatively correlated with HDL-C and eGFR(P＜0).05).ROC curve analysis showed that,the area under the curve of serum HIF-1α and ChREBP levels alone and combined diagnosis of T2DKD was 0.784,0.787 and 0.882 respectively,and the area under the curve of combined diagnosis of HIF-1α and ChREBP levels was greater than that of each index alone(P＜0.05).Conclusion:The increase of serum HIF-1α and ChREBP levels in T2DKD patients is re-late to the disorder of glucose and lipid metabolism and the decrease of renal function,the combination of serum HIF-1α and ChREBP levels has certain value in the diagnosis of T2DKD.
Type 2 diabetic kidney diseaseHIF-1αChREBPGlucose and lipid metabolismRenal functionDiagnostic value
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