Effects of Modified Tianma Gouteng Decoction on Cerebral Hemodynamics,Oxidative Stress and Nerve Cell Factors in Patients with Cerebral Infarction Convalescence
Objective:To investigate the effects of tianma gouteng decoction on cerebral hemodynamics,oxidative stress and nerve cell factors in patients with cerebral infarction convalescence.Methods:108 patients with cerebral infarction convalescence who were treated in The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from April 2020 to December 2022 were selected,and divided into control group and combined group according to random number table method,with 54 cases in each group.Patients in control group received routine treatment,and patients in combined group received tianma gouteng decoction on the ba-sis of control group.The chinese medicine syndrome scores,cerebral hemodynamics,Barthel index score,oxidative stress index,national institutes of health stroke scale(NIHSS)score and nerve cell factor were compared between two groups.Results:Compared with control group 2 months after treatment,the chinese medicine syndrome scores such as hemianesthesia,hemiplegia,strong tongue,dizziness and headache,red face and red eyes and bitter and dry mouth in combined group were lower(P＜0.05).Compared with control group 2 months after treatment,the NIHSS score in combined group was lower and the Barthel index score was higher(P＜0.05).Compared with control group 2 months after treatment,combined group had lower pulsatility index(PI),higher mean blood flow velocity(Vm)and peak systolic blood flow velocity(Vs)(P＜0.05).Compared with control group 2 months after treatment,combined group had lower malondi-aldehyde(MDA)and higher superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)(P＜0.05).Compared with control group 2 months after treatment,combined group had lower myelin basic protein(MBP),higher nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)(P＜0.05).Conclusion:Modified tianma gouteng decoction can promote the improvement of clinical symp-toms,reduce neurological impairment,improve cerebral hemodynamics,reduce oxidative stress,improve the secretion of nerve cell fac-tors and improve self-care ability in patients with cerebral infarction convalescence.
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