Effects of Nasal High Flow Warming Humidification Oxygen Inhalation Combined with Salvia Miltiorrhiza Injection in the Treatment of AECOPD with Mild Type Ⅱ Respiratory Failure and Its Impact on Blood Gas and Lung Function
Objective:To explore the effect of nasal high flow warming humidification oxygen inhalation combined with salvia miltiorrhiza injection in the treatment of AECOPD with mild type Ⅱ Respiratory failure and the impact on blood gas and lung function of patients.Methods:88 AECOPD patients with mild type II Respiratory failure admitted to the First Department of Intensive care medicine of our hospital from March 2020 to February 2023 were divided into the matched group and the observation group,with 44 cases in each group.Both groups were treated with nasal high flow heating and humidification oxygen inhalation,and on this basis,the observation group patients were given Danshen injection drops.The clinical efficacy of the two groups of patients was compared,as well as the blood gas indicators[arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)],pulmonary function in-dicators[1 s forced expiratory volume(FEV1),FEV1/forced Vital capacity(FEV1/FVC)and FEV1％of the estimated value],inflammatory factors[interleukin 6(IL-6),IL-8,tumor necrosis factor α(TNF-α)]and serum biochemical indicators[transforming growth factor β 1(TGF-β1)Endothelin-1(ET-1),connective tissue growth factor(CTGF)]levels.Results:(1)The total effective rates of observation group higher than matched group(P＜0.05).(2)After treatment,PaO2 significantly increased and PaCO2 decreased in both groups(P＜0.05).After treatment,observation group was higher than matched group,while PaCO2 was significantly lower than matched group(P＜0.05).(3)After treatment,FEV1,FEV1/FVC,and FEV1％increased in both groups(P＜0.05).observation group were higher than matched group after treatment(P＜0.05).(4)The levels of serum IL-6,IL-8,and TNF-α after treatment in two groups were significantly reduced(P＜0.05).The levels of serum IL-6,IL-8,and TNF-α in observation group after treatment were lower than matched group(P＜0.05).(5)The levels of serum TGF-β1,ET-1 and CTGF of the two groups after treatment were significantly reduced(P＜0.05),the levels of serum TGF-β1,ET-1 and CTGF of observation group after treatment in observation group were lower than matched group(P＜0.05).Conclusion:Nasal high flow warming humidification oxygen inhalation combined with salvia miltiorrhiza injection in the treatment of AECOPD with typeⅡ Respiratory failure has a positive effect,can significantly improve the blood gas and lung function of patients,reduce inflammatory reactions.
AECOPDType Ⅱ Respiratory failureTransnasal high flow heating humidification oxygen inhalationDanshen Injec-tionBlood gasPulmonary function
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