Predictive Value of DCE-MRI Quantitative Parameters Combined with NLR and MLR in Predicting the Prognosis of Brain Glioma Patients
Objective:To study the predictive value of Dynamic contrast-enhanced scanning-magnetic resonance examination(DCE-MRI)quantitative parameters combined with neutrophil-lymphocyte radio(NLR)and monocyte lymphocyte ratio(MLR)in the prognosis of brain glioma patients.Methods:130 brain glioma patients who received treatment in our hospital from January 2020 to June 2022 were selected as the observation objects.All patients were treated with radiotherapy after brain glioma resection.According to the prognosis evaluation,it was divided into good prognosis group(n=48)and poor prognosis group(n=82).Compare DCE-MRI quantitative parameters,NLR and MLR in two groups;Unvariate and multivariate analysis of the factors affecting poor patient outcomes;The predic-tive value of the DCE-MRI quantitative parameters combined with NLR and MLR was analyzed using the receiver operating characteris-tic(ROC)curve.Results:There was no loss to follow-up at 1 year,and the levels of transport constant(Ktrans),extravascular space vol-ume percentage(Ve),NLR and MLR in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).The proportion of age,tumor grade Ⅲ～Ⅳ,low differentiation and postoperative radiotherapy in the poor prognosis group were higher than those in the good prognosis group(P＜0.05),and the Kamofsky Performance Status(KPS)score was lower than that in the good prognosis group(P＜0.05).Univariate and multivariate Logistic regression analysis found that the factors associated with poor prog-nosis included Ktrans,Ve,NLR and MLR(P＜0.05).The ROC curve analysis found that found that DCE-MRI quantitative parameters Ktrans,Ve combined with NLR and MLR had the highest predictive value for patients with poor prognosis,the area under the curve(AUC)was 0.874,and the sensitivity was 95.21％,which was significantly higher than the results of other individual tests.Conclusion:NLR,MLLR and DCE-MRI quantitative parameters are abnormally elevated in glioma patients with poor prognosis,with three combina-tions can improve the predictive value in the prognosis of brain glioma patients,and it is worth promoting and applying in clinical diag-nosis.
DCE-MRI quantitative parametersNLRMLRBrain gliomaPrognosisPredictive value
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