Effects of Repetitive Transcranial Magnetic Stimulation on Neurological Function Indexes and Peripheral Blood NLRP3 Inflammasome in Patients with Post-Stroke Cognitive Impairment
Objective:To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)on neurological function indexes and peripheral blood nod-like receptor protein 3(NLRP3)inflammasome in patients with post-stroke cognitive impairment(PSCI).Methods:98 PSCI patients who were admitted to Guangdong Sanjiu Brain Hospital from April 2020 to May 2022 were selected,patients were divided into control group(conventional drug therapy and rehabilitation training,n=49)and experimental group(rTMS on the basis of control group,n=49)according to the random number table method.The scale scores,neurological function indexes and peripheral blood NLRP3 inflammasome were compared between two groups.Results:4 weeks after treatment,the scores of mini-mental state examination(MMSE),Montreal cognitive assessment(MoCA)and modified Barthel index(MBI)in experimental group were higher than those in control group(P＜0.05).The levels of glial fibrillary acidic protein(GFAP),neuron-specific enolase(NSE)and S100β in experimental group were lower than those in control group(P＜0.05).The peripheral blood NLRP3 mRNA,interleukin-18(IL-18)and interleukin-1 β(IL-1β)in experimental group were lower than those in control group(P＜0.05).Conclusion:The treatment of PSCI with rTMS can effectively reduce the cognitive dysfunction of patients,improve the ability of self-care,and regulate the neurological function index and peripheral blood NLRP3 inflammasome.
Repetitive transcranial magnetic stimulationStrokeCognitive impairmentNeurological functionNLRP3 inflamma-some
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