Study on the Relationship between Coagulation and Fibrinolysis Indexes and Acute Traumatic Coagulopathy after Craniocerebral Injury and the Predictive Efficacy of Cerebrocardiac Syndrome
Objective:To analyze the relationship between coagulation and fibrinolysis indicators and acute traumatic coagulopa-thy(ATC)after traumatic brain injury(TBI)and their predictive efficacy for cerebrocardiac syndrome(CCS).Methods:80 patients with TBI admitted to our hospital from January 2020 to December 2022 were selected as the research objects.The levels of prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D),thrombin-antithrombin complex(TAT),plasminogen-α2 plasmino-gen inhibitor complex(PIC),international normalized ratio(INR)and TAT/PIC ratio were detected and calculated in non-ATC patients and ATC patients,non-CCS patients and CCS patients,respectively.Bivariate Spearman correlation was used to test the correlation be-tween coagulation and fibrinolysis indicators.Multivariate Logistic model was established to analyze the influencing factors of ATC and TBI combined with CCS after TBI,and the predictive efficacy of coagulation and fibrinolysis indicators on TBI combined with CCS was analyzed.Results:The incidence of ATC in 80 TBI patients was 27.50％.Compared with the non-ATC group,the levels of PT,APTT and D-D in the ATC group were higher,and the TAT/PIC ratio was lower(P＜0.05).PT,APTT and D-D were positively correlated with ATC after craniocerebral injury,and TAT/PIC was negatively correlated with ATC.Multivariate logistic analysis showed that TAT/PIC was an independent risk factor for ATC after craniocerebral injury(P＜0.05).The incidence of CCS in 80 TBI patients was 20.00％.Compared with the non-CCS group,the levels of PT,APTT and D-D in the CCS group were higher,and the TAT/PIC ratio was lower(P＜0.05).Multivariate logistic analysis showed that PT,APTT,D-D and TAT/PIC were independent risk factors for TBI combined with CCS(P＜0.05).In the prediction of TBI combined with CCS,the ACU of PT,APTT and D-D were all＞0.70,and TAT/PIC＞0.85.Conclusion:TAT/PIC is associated with ATC after TBI,and can also predict the occurrence of CCS,which has guiding significance in the prognosis prediction of TBI patients.
TBIATCCCSCoagulation indexFibrinolytic indexPredictive value
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