Study on the Relationship between Serum HIF-1α,HSP27,HSP70,HSP90αand the Efficacy of Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
Objective:To investigate the relationship between serum hypoxia-inducible factor-1α(HIF-1α),heat shock prot:ein(HSP)27,HSP70,HSP90α and the efficacy of transarterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC).Methods:125 HCC patients who were received TACE treatment in Nanchong Central Hospital from June 2021 to June 2023 were selected,and patients were divided into ineffective group(47 cases)and effective group(78 cases)according to the efficacy of TACE treatment.Serum HIF-1α,HSP27,HSP70 and HSP90α were detected by enzyme-linked immunosorbent assay.The efficacy of TACE in HCC patients were analyzed by multivariate Logistic regression analysis.The predictive value of serum HIF-1α,HSP27,HSP70 and HSP90α for the ineffective of TACE in HCC patients were analyzed by receiver operating characteristic(ROC)curve.Results:Com-pared with effective group,the levels of serum HIF-1α,HSP27,HSP70 and HSP90α in ineffective group were increased(P＜0.05).Multi-variate Logistic regression analysis showed that,poor differentiation,vascular invasion and increased levels of HIF-1α,HSP27,HSP70 and HSP90α were independent risk factors for ineffective TACE treatment in HCC patients(P＜0.05).The area under the curve of serum HIF-1α,HSP27,HSP70 and HSP90α combined to predict the ineffective of TACE in HCC patients was 0.958,which was greater than the 0.750,0.739,0.742 and 0.749 predicted by serum HIF-1α,HSP27,HSP70 and HSP90α alone.Conclusion:The increase of serum HIF-1α,HSP27,HSP70 and HSP90α is an independent risk factor for the ineffective of TACE in HCC patients,the combination of serum HIF-1α,HSP27,HSP70 and HSP90α has a high value in predicting the ineffective of TACE in HCC patients.
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