Study on the Relationship between Serum microRNA-141-3p,microRNA-150-5p and Clinical Pathological Characteristics and Radiotherapy Sensitivity in Patients with Nasopharyngeal Carcinoma
Objective:To explore the relationship between serum microribonucleic acid(miRNA)-141-3p,miR-150-5p and clini-cal pathological characteristics and radiotherapy sensitivity in patients with nasopharyngeal carcinoma(NPC).Methods:92 NPC patients with who were underwent radiotherapy in our hospital from January 2019 to July 2022 were collected as NPC group,they were divided into resistance group and sensitivity group based on the efficacy of radiotherapy,and another 80 healthy volunteers who were underwent physical examination in our hospital during the same period were selected as control group.The expression of serum miR-141-3p and miR-150-5p between control group and NPC group were compared.The relationship between the expression of serum miR-141-3p,miR-150-5p and clinical pathological characteristics in patients with NPC was analyzed.The influencing factors of radiotherapy resis-tance in patients with NPC was analyzed by univariate and multivariate Logistic regression.Results:Compared with control group,the expression of serum miR-141-3p increased in NPC group,and the expression of miR-150-5p decreased(P＜0.05).The expression of serum miR-141-3p and miR-150-5p in patients with NPC showed significant differences in different degrees of differentiation,TNM stage,and lymph node metastasis(P＜0.05).The incidence of radiation resistance in 92 patients with NPC was 22.83％(21/92).Univariate analysis showed that the proportion of TNM stage Ⅲ-Ⅳa and miR-141-3p ≥ 2.60 were higher in the resistant group than in the sensitive group,and the proportion of miR-150-5p ≥ 0.80 was lower than in the sensitive group(P＜0.05).Multivariate Logistic regression analysis showed that miR-141-3p ≥ 2.60 was the independent risk factor of radiation resistance in patients with NPC,and miR-150-5p ≥ 0.80 was the independent protective factor(P＜0.05).Conclusion:High expression of serum miR-141-3p in patients with NPC,low expression of miR-150-5p,which are related to degrees of differentiation,TNM stage,lymph node metastasis,and radiotherapy sensitivity,and which are expected to become the evaluation indicators of radiotherapy resistance in NPC patients.
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