Changes in Serum CAT,T-AOC,ROS Levels and Their Relationship with Prognosis in Critically Ill Patients with Ventricular Hemorrhage
Objective:To investigate the changes in serum catalase(CAT),total antioxidant capacity(T-AOC),reactive oxygen species(ROS)levels and their relationship with prognosis in critically ill patients with ventricular hemorrhage.Methods:90 critically ill patients with ventricular hemorrhage admitted to our hospital from January 2020 to January 2023 were selected as the study subjects and divided into an observation group.In addition,90 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group.The serum CAT,T-AOC,and ROS levels of the two groups of patients were compared,and the subject characteristic working curve was established to analyze the diagnostic efficacy of serum CAT,T-AOC,and ROS in critically ill ventricular hemorrhage.After treatment,all patients were evaluated using the Glasgow prognosis(GOS)score.35 patients with a GOS score of less than 4 were divided into a poor prognosis group,and 55 patients with a GOS score of≥4 were divided into a good progno-sis group.The general clinical situation of the two groups of patients was compared,and logistic regression analysis was used to analyze the predictive value of CAT,T-AOC,and ROS levels for the prognosis of critically ill patients with ventricular hemorrhage.Results:There was a significant difference in the levels of serum CAT,T-AOC,and ROS between the two groups of patients.The levels of CAT,T-AOC in the observation group were lower than those in the control group,while ROS was higher than those in the control group(P＜0.05);The area under the curve(AUC)is sequentially ROS(0.688),CAT(0.667),T-AOC(0.656),and a combination of the three(0.671).The diagnostic sensitivity of ROS is 67.61％,the specificity is 66.85％,the diagnostic sensitivity of CAT is 60.03％,the specificity is 67.53％,the diagnostic sensitivity of T-AOC is 61.24％,the specificity is 66.53％,and the combined diagnostic sensitivity of the three is 74.58％,the specificity is 86.32％;There was no significant difference in gender,age,BMI,comorbidities,and comparison between the patients with good prognosis and those with poor prognosis(P＞0.05).There was a significant difference in treatment time,APACHE Ⅱscore,bleeding volume,CAT,T-AOC,and ROS levels between the two groups(P＜0.05);The results of logistic regression analysis showed that bleeding volume,APACHE Ⅱ score,CAT,T-AOC,and ROS were independent influencing factors for poor prognosis of critically ill ventricular hemorrhage(P＜0.05).Conclusion:The levels of CAT,T-AOC,and ROS in critically ill patients with ventricular hemorrhage will undergo significant changes,and the combination of the three has a higher diagnostic value for critically ill patients with ventricular hemorrhage than a single diagnosis.Moreover,CAT,T-AOC,and ROS can serve as independent prognostic factors for criti-cally ill ventricular hemorrhage.Therefore,in clinical practice,patients with decreased CAT,T-AOC,and elevated ROS levels should be vigilant for the occurrence of poor prognosis.
Severe intraventricular hemorrhageCatalaseTotal antioxidant capacityReactive oxygen speciesPrognosis
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