Effect of Chaiqin Chengqi Decoction Adjuvant Therapy on Th17/Treg Immune Imbalance and Peripheral Blood TLR4/NF-κB Pathway mRNA Expression in Patients with Acute Pancreatitis
Objective:To observe the effect of chaiqin chengqi decoction adjuvant therapy on helper T cell 17(Th17)/regulatory T cell(Treg)immune imbalance and peripheral blood Toll-like receptor 4(TLR4)/nuclear factor-KB(NF-κB)pathway mRNA expression in patients with acute pancreatitis(AP).Methods:90 AP patients who were admitted to Chengdu First People's Hospital from March 2021 to December 2022 were included.Patiens were divided into control group and experimental group according to the random number table method,45 cases in each group.Patients in control group were treated with conventional western medicine,and patients in experi-mental group were treated with chaiqin chengqi decoction on the basis of control group.The efficacy,chinese medicine syndrome scores,Th17/Treg immune imbalance related indicators,and peripheral blood TLR4/NF-κB pathway mRNA expression were compared between two groups.Results:The total clinical effective rate in experimental group was higher than that in control group(P＜0.05).1 week after treatment,the chinese medicine syndrome scores syndromes of severe abdominal pain,fullness and dryness,hot flashes,nausea and vom-iting,and short red urine in two groups decreased,and those in experimental group were lower than control group(P＜0.05).1 week after treatment,the proportion of Th 17 cells and Th17/Treg in two groups decreased,and those in experimental group were lower than control group(P＜0.05).1 week after treatment,the proportion of Treg cells in two groups increased,and those in experimental group were higher than control group(P＜0.05).1 week after treatment,TLR4 mRNA and NF-κB mRNA in two groups decreased,and those in experimental group were lower than control group(P＜0.05).Conclusion:Chaiqin chengqi decoction adjuvant treatment of AP patients can improve the therapeutic effect,reduce chinese medicine syndrome scores,regulate Th17/Treg immune imbalance and peripheral blood TLR4/NF-κB pathway mRNA expression.
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