The Relationship between EFI Score,Serum MMIF,YKL-40 and Ovarian Function,Clinical Stage of Patients with Endometriosis
Objective:To explore the relationship between fertility index(EFI)score,serum macrophage migration inhibitory fac-tor(MMIF),Chitin enzyme protein 40(YKL-40),ovarian function and clinical stage of patients with Endometriosis.Methods:Eighty pa-tients with Endometriosis admitted to our hospital from June 2020 to June 2023 were selected as the study subjects,and they were divided into an observation group.Eighty healthy female volunteers who came to our hospital for physical examination at the same time were se-lected as the control group.The EFI score,serum MMIF,YKL-40 and the expression level of ovarian function indicators of the two groups were compared.Eighty patients with Endometriosis were classified according to the American Association of Reproductive Medicine Endometriosis staging criteria(r-AFS),including 15 patients with stage Ⅰ,23 patients with stage Ⅱ,25 patients with stage Ⅲ,and 17 patients with stage Ⅳ.The EFI scores,serum MMIF,and YKL-40 expression levels in patients with different r-AFS stages were compared.And the Spearman correlation analysis method was used to analyze the correlation between EFI score,serum MMIF,YKL-40,and ovarian function indicators.Results:The EFI score of the observation group was lower than that of the control group,and the expres-sion levels of serum MMIF and YKL-40 were higher than those of the control group(P＜0.05);The expression levels of anti Mullerian hormone(AMH),Luteinizing hormone(LH)and follicle stimulating hormone(FSH)in the observation group were lower than those in the control group,and the level of estradiol(E2)was higher than that in the control group(P＜0.05);The EFI scores of patients with En-dometriosis in different stages from high to low were stage Ⅰ,stage Ⅱ,stage Ⅲ,and stage Ⅳ,and the levels of MMIF and YKL-40 from high to low were stage Ⅳ,stage Ⅲ,stage Ⅱ,and stage Ⅰ.The EFI scores,serum MMIF,and YKL-40 expression levels in different stages were significantly different(P＜0.05);The Spearman correlation analysis showed that the EFI score was positively correlated with AMH,LH,FSH,and negatively correlated with E2(P＜0.05).MMIF and YKL-40 were negatively correlated with AMH,LH,FSH,and positively correlated with E2(P＜0.05).Conclusion:EFI score,serum MMIF,and YKL-40 levels are significantly correlated with the ovary of Endometriosis patients,and there are significant differences between the EFI score,serum MMIF,and YKL-40 levels of different Endometriosis patients.Clinical application of EFI score,serum MMIF,and YKL-40 levels can be considered to assist in judging the ovarian function and disease severity of Endometriosis patients.
Fertility indexMacrophage migration inhibitory factorChitin enzyme protein 40EndometriosisOvarian functionClinical stages
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