Prediction Value of Color Doppler Ultrasound Signs Combined with Serum Tg and TSH in Cervical Lymph Node Metastasis of Thyroid Micropapillary Carcinoma
Objective:To study the predictive value of color doppler ultrasound signs combined with serum thyroglobulin(Tg)and thyroid stimulating hormone(TSH)in cervical lymph node metastasis occurred of papillary thyroid microcarcinoma(PTMC).Methods:A total of 102 researchers were included in the retrospective analysis,all patients with PTMC who were admitted to Haikou Hospital Affiliated to Xiangya Medical College of Central South University from January 2017 to June 2022.They were divided into metastasis group with 35 cases and non-metastasis group with 67 cases according to whether cervical lymph node metastasis occurred.Color doppler ultrasound signs and serum Tg and TSH levels were compared between the two groups.The influencing factors of cervical lymph node metastasis of PTMC were identified by multivariate logistic regression analysis.The efficacy of.color doppler ultrasound signs and serum levels of Tg and TSH in predicting cervical lymph node metastasis of PTMC was analyzed by ROC curve.Results:-The percentage of lesions with irregular shape,presence of microcalcifications,tumor size ≥ 0.5 cm,and number of tightly packed envelopes was 91.43％,60.00％,40.00％,48.57％in the metastasis group respectively,which was higher compared to 74.63％,32.84％,17.91％,23.88％in the no metastasis group(all P＜0.05);There were no significant differences in the contrast of echo,border,blood flow signs,FT3,FT4 between the two groups(all P＞0.05);Serum TG and TSH levels were higher in the metastasis group compared to those in the no metastasis group(all P＜0.05).Available from multiple logistic regression analysis:irregular shape of the lesions,presence of microcal-cifications as well as serum TG＞2 ng/mL,TSH＞0.5 mIU/L,tumor size≥0.5 cm and close adherence to the envelope were all risk fac-tors for cervical lymph node metastasis in PTMC(P＜0.05).After ROC curve analysis,we found that the area under the curve,sensitivity as well as specificity of color doppler ultrasound signs combined with serum TG and TSH in predicting the occurrence of cervical lymph node metastasis from PTMC were higher than those of the above indicators alone.Conclusion:Color doppler ultrasound signs combined with serum Tg and TSH have high value in predicting cervical lymph node metastasis of PTMC.In addition,irregular lesion shape,microcalcification,serum Tg＞2 ng/mL,TSH＞0.5 mIU/L,tumor size ≥0.5 cm,and close to the capsule are all risk factors for cervical lymph node metastasis of PTMC.
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