Efficacy and Safety of Low Dose Glucocorticoid Combined with Continuous Blood Purification in the Treatment of Severe Sepsis in Children
Objective:To analyze the efficacy and safety of low dose glucocorticoid combined with continuous blood purification in the treatment of severe sepsis in children.Methods:A total of 102 children with severe sepsis from January 2021 to January 2023 were selected as research objects and randomly divided into matched group and observation group,with 51 cases in each group.The matched group was given classical treatment,and the observation group was given low-dose glucocorticoid combined with continuous blood pu-rification on the basis of the matched group.The information of the two groups after treatment was recorded.The peripheral blood lactic acid,central venous oxygen saturation(ScvO2),serum inflammation index,PCIS score,APACHE Ⅱ score before and after treatment were compared between the two groups,and the occurrence of main complications was observed.Results:Compared with the matched group,mechanical ventilation,hypotension and admission to the ICU were shorter,and the rate of stopping the booster within 7 d was higher(P＜0.05).There was no difference in 28 d mortality between the two groups(P＞0.05).After treatment,the levels of lactic acid,pro-calcitonin(PCT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in observation group were lower than those in matched group,while the level of ScvO2 was higher than that in matched group(P＜0.05).After treatment,PCIS score of observation group was higher than that of matched group,APACHE Ⅱ score was lower than that of matched group(P＜0.05).The incidence of main complications in the observation group was lower than matched group(P＜0.05).Conclusion:Low-dose glucocorticoid combined with continuous blood purification treatment is conducive to the disease outcome of children with severe sepsis,reduce the occurrence of major complications,and may be related to the blockade of inflammatory response,which deserves further research and application.
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