Application Value of Endometrial Receptivity Test in Frozen-Thawed Embryo Transfer in Patients with Repeated Implantation Failure and its Influencing Factors of Clinical Pregnancy
Objective:To explore the application value of endometrial receptivity test(ERT)in frozen-thawed embryo transfer(FET)in patients with repeated implantation failure,and to analyze the influencing factors of clinical pregnancy.Methods:The clinical data of 150 patients with repeated implantation failure who were admitted to Hainan Women and Children's Medical Center from Octo-ber 2019 to April 2022 were retrospectively analyzed,patients were divided into ERT group(n=78,received ERT technology)and non-ERT group(n=72,did not receive ERT technology)according to whether they received ERT technology.Patients were divided into clinical pregnancy group and non-clinical pregnancy group according to the clinical pregnancy of patients with repeated implantation fail-ure.The influencing factors of clinical pregnancy were analyzed by univariate and multivariate Logistic regression models.Results:There was no significant difference in ectopic pregnancy rate between two groups(P＞0.05).The clinical pregnancy rate and live birth rate in ERT group were higher than those in non-ERT group,the endometrial thickness on the day of transplantation was greater than that in non-ERT group,the number of transplanted embryos was less than that in non-ERT group,and the abortion rate was lower than that in non-ERT group(P＜0.05).All patients were divided into clinical pregnancy group(n=85)and non-clinical pregnancy group(n=65).The results of univariate analysis showed that,clinical pregnancy was related to age,type of transplanted embryos,number of transplanted embryos,total number of cycles,FSH,endometrial thickness and endometrial type(P＜0.05),and it was not related to body mass index(BMI),infertility years,infertility type,and Embryos were cryopreserved for the storage time(P＞0.05).Multivariate Logistic regression analysis showed that,older age and higher FSH were risk factors for clinical pregnancy,while type of transplanted embryos is blastocyst and more transplanted embryos were protective factors for clinical pregnancy(P＜0.05).Conclusion:ERT technology can effectively im-prove the clinical pregnancy of patients with repeated implantation failure in FET.Age,FSH,type of transplanted embryos and number of transplanted embryos are the influencing factors of clinical pregnancy.
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