Effect of Traditional Chinese Medicine Enema on Clinical Efficacy and Serum IL-1β,IL-8 and TNF-α Levels in Patients with Acute Radiation Proctitis of Cervical Cancer
Objective:To investigate the effect of traditional chinese medicine enema on clinical efficacy and serum levels of in-terleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)in patients with acute radiation proctitis(ARP)of cervical cancer.Methods:180 patients with cervical cancer ARP who underwent radiotherapy in Shaoyang Central Hospital from March 2021 to March 2023 were selected,patients were divided into A group(conventional treatment,n=90)and B group(traditional chinese medicine enema on the basis of A group,n=90)by random number table method.The clinical efficacy,efficacy radiation injury,chinese medicine syndrome scores and serum IL-1β,IL-8 and TNF-α levels in two groups were observed.And compare of serum IL-1β,IL-8 and TNF-αlevels in patients with different grades of radiation proctitis.Results:The total clinical effective rate in B group was higher than that in A group(P＜0.05).The scores of mucous bloody stool,abdominal pain,tenesmus,loose stool or constipation,anal burning pain,mouth dry mouth bitter and red urine in two groups decreased after treatment,and those in B group were lower than those in A group(P＜0.05).The total effective rate of radiation injury in B group was higher than that in A group(P＜0.05).Serum IL-1 β,IL-8 and TNF-α levels in grades of radiation proctitis Ⅲ and Ⅱ were higher than grade Ⅰ,and grade Ⅲ was higher than that of grade Ⅱ(P＜0.05).Serum IL-1 β,IL-8 and TNF-α levels in two groups decreased after treatment,and those in B group were lower than A group(P＜0.05).Conclusion:Chinese medicine enema in the treatment of cervical cancer ARP patients can improve the clinical efficacy and clinical symptoms,which may be relate to the improvement of serum IL-1β,IL-8 and TNF-α levels.
Traditional chinese medicine enemaCervical cancerAcute radiation proctitisClinical efficacyIL-1βIL-8TNF-α
NETL
NSTL
万方数据
