Effects of Xiaoer Feire Kechuan Granules Combined with Acetylcysteine Solution for Aerosol Inhalation on Pulmonary Ventilation Function,Inflammatory Factor and Immunoglobulin in Children with Bronchial Pneumonia
Objective:To observe the effects of xiaoer feire kechuan granules combined with acetylcysteine solution for aerosol inhalation on pulmonary ventilation function,inflammatory factor and immunoglobulin in children with bronchial pneumonia.Methods:100 children with bronchial pneumonia who were admitted to theHefei Second People's Hospital from September 2019 to January 2023 were selected,and children were divided into control group and study group by double chromosphere method,with 50 cases in each group.Children in control group were treated with acetylcysteine solution for aerosol inhalation,and children in study group were treated with xiaoer feire kechuan granules on the basis of control group.The clinical symptoms,inflammatory factor levels[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)],immunoglobulin[immunoglobulin(Ig)A,IgM,IgG],pulmonary ventilation function in-dexes[inspiratory time(TI),expiratory time(TE),inspiratory-expiratory ratio(TI/TE),peak time ratio(TPF％TE),peak volume ratio(VPF％VE)]and incidence of adverse reactions were compared between two groups.Results:Compared with control group,the disap-pearance time of lung wet rales,disappearance time of cough,disappearance time of expectoration and disappearance time of fever in study group were shorter(P＜0.05).CRP,IL-6 and PCT in study group were lower than those in control group 10 days after treatment(P＜0.05).IgA,IgM and IgG in study group were higher than those in control group 10 days after treatment(P＜0.05).TI,TE,TI/TE,TPF％TE and VPF％VE in study group were higher than those in control group 10 days after treatment(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:The combination of xiaoer feire kechuan granules and acetylcysteine solution for aerosol inhalation in the treatment of bronchial pneumonia could effectively shorten the remission time of clin-ical symptoms,improve pulmonary ventilation function,reduce the level of inflammatory factor,regulate immunoglobulin,and had good safety.
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