Study on the Relationship between Serum Estrogen Level in Early Pregnancy and the Risk of Hypertensive Disorder Complicating Pregnancy
Objective:To investigate the relationship between serum estradiol(E2)level in early pregnancy and the risk of hyper-tensive disorder complicating pregnancy(HDCP).Methods:100 HDCP patients(HDCP group)who were admitted to our hospital from December 2021 to December 2022 were selected,and 80 healthy pregnant women who underwent prenatal examination during the same period were selected as control group,patients were divided into gestational hypertension group(26 cases),preeclampsia-eclampsia group(35 cases),pregnancy with chronic hypertension group(21 patients),and chronic hypertension with preeclampsia group(18 patients)according to the HDCP classification.Serum E2 levels were detected,and the differences of serum E2 levels in different groups were com-pared.The risk factors affecting the incidence of HDCP were analyzed by Logistic regression analysis.The value of serum E2 level in pre-dicting HDCP were analyzed by receiver operating characteristic(ROC)curve.Results:The serum E2 level in HDCP group was lower than that in control group(P＜0.05),The serum E2 level of the preeclampsia-eclampsia group was lower than that of the chronic hyperten-sion with preeclampsia group,the pregnancy with chronic hypertension group and the pregnancy with hypertension group(P＜0.05),and the serum E2 level of chronic hypertension with preeclampsia group was lower than that of pregnancy with chronic hypertension group and the pregnancy with hypertension group(P＜0.05).Age≥35 years old,high pre-pregnancy BMI,parity≥2 times,family history ofhyper-tension,and maternal history of HDCP were risk factors for HDCP(P＜0.05),and E2 was a protective factor(P＜0.05).The critical value of E2 in predicting HDCP was 162.35 ng/L,the area under the curve was 0.744,the sensitivity was 79.00％,and the specificity was 76.25％.Conclusion:The level of serum E2 in early pregnancy of HDCP patients was significantly decrease,which is relate to the aggravation of HDCP,the detection of E2 level could predict the risk of HDCP.
Early pregnancyEstrogenHypertensive disorders complicating pregnancyInfluencing factors
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