Effects of Rehabilitation Training Combined with Hyperbaric Oxygen on Cerebrovascular Dynamics,Vascular Endothelial Function and Serum NSE,UCH-L1 and GFAP in Patients with Hypertensive Cerebral Hemorrhage after Operation
Objective:To observe the effects of rehabilitation training combined with hyperbaric oxygen on cerebrovascular dynamics,vascular endothelial function and serum neuron specific enolase(NSE),ubiquitin carboxyl terminal hydrolase(UCH-L1)and glial fibrillary acidic protein(GFAP)in patients with hypertensive cerebral hemorrhage after operation.Methods:112 patients with hypertensive intracerebral hemorrhage who underwent minimally invasive drilling and drainage surgery at our hospital from March 2021 to December 2022 were divided into a control group(n=56,receiving routine rehabilitation training)and an observation group(n=56,combining hyperbaric oxygen intervention with the control group)according to the random number table method.The scale scores[activities of daily living scale-modified Barthel index(MBI),Fugl-Meyer motor function rating scale(FMA),National Institutes of Health Stroke Scale(NIHSS)],cerebrovascular dynamics indexes[mean blood flow(Qmean),peripheral resistance(R),mean blood flow velocity(Vmean)],vascular endothelial function[endothelin-1(ET-1),nitric oxide(NO)],serum NSE,UCH-L1,GFAP levels and adverse reactions were compared between two groups.Results:Compared with control group after intervention,the MBI and FMA scores in observation group were higher,and the NIHSS score was lower(P＜0.05).Compared with control group after intervention,the Vmean and Qmean in observation group were higher,and the R was lower(P＜0.05).Compared with control group after intervention,NSE,UCH-L1 and GFAP in observation group were lower(P＜0.05).Compared with control group after intervention,NO was higher and ET-1 was lower in observation group(P＜0.05).There was no difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusion:Rehabilitation training combined with hyperbaric oxygen intervention in patients with hypertensive intracerebral hemorrhage after operation,which can effectively improve cerebrovascular dynamics,vascular endothelial function and serum NSE,UCH-L1,GFAP levels,reduce neurological damage,and improve self-care ability.
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