The Expression Levels of Serum HMGB1,AT and Inflammatory Factors in Patients with Acute Trauma and their Correlation with Thrombosis were Analyzed
Objective:The expression levels of serum high mobility group protein B1(HMGB1),antithrombin(AT)and inflammatory factors in patients with acute trauma and their correlation with thrombosis were analyzed.Methods:90 patients with acute trauma admitted to our hospital from January 2020 to December 2022 were included in the observation group,and the thrombosis rate was recorded.In addition,50 healthy subjects who underwent physical examination in our hospital during the same period were included in the control group.The levels of serum HMGB1,AT and inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),interleukin-1 β(IL-1)]in the observation group,the control group and patients with or without thrombosis were detected.The correlation between serum HMGB1,AT and inflammatory factors and thrombosis was tested by bivariate Spearman correlation method.Multivariate Logistic model was established to analyze the independent risk factors of thrombosis in patients with acute trauma.The predictive efficacy of serum HMGB1,AT and inflammatory factors in thrombosis in patients with acute trauma was analyzed.Results:Compared with the control group,the serum levels of HMGB1,IL-6,IL-10 and IL-1β in the observation group were higher,and the serum AT level was lower(P＜0.05).Compared with the non-thrombosis group,the serum levels of HMGB1,IL-6,IL-10 and IL-1β in the thrombus group were higher,and the serum AT level was lower(P＜0.05).Thrombosis in patients with acute trauma was positively correlated with serum HMGB1,IL-6,IL-10 and IL-1β,and negatively correlated with serum AT(P＜0.05).Multivariate Logistic analysis showed that serum HMGB1,AT,IL-6,IL-10 and IL-1β were independent risk factors for thrombosis in patients with acute trauma(P＜0.05).The predictive value of serum HMGB1,AT,HMGB1+AT+inflammatory factors for thrombosis in patients with acute trauma was higher,and the AUC values were 0.868,0.857 and 0.912,respectively.The predictive value of serum IL-6,IL-10 and IL-1β for thrombosis in patients with acute trauma was general,and the AUC values were 0.761,0.758,0.784 and 0.767,respectively.Conclusion:Serum HMGB1,AT and inflammatory factors are associated with acute trauma and thrombosis.The injury and thrombosis risk of patients with acute trauma can be evaluated and predicted according to the changes of their index levels.
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