The Relationship between Angiopoietin-like Protein 4 and Type Ⅱ Alveolar Cell Surface Antigen 6 and the Severity of Acute Respiratory Distress Syndrome and the Efficacy of Evaluating the Prognosis
Objective:To analyze the relationship between ANGPTL4(ANGPTL4)and type Ⅱ alveolar cell surface antigen-6(KL-6)and the severity and prognosis of acute respiratory distress syndrome.Methods:120 patients with acute respiratory distress syndrome admitted to our hospital from January 2020 to December 2022 were selected as study subjects(observation group),and divided into mild group,moderate group and severe group according to oxygenation index(PaO2/FiO2).Another 120 non-acute respiratory distress syndrome patients were selected as control group.The expression levels of serum ANGPTL4 and KL-6 in all patients were detected,and the relationship between serum ANGPTL4 and KL-6,APACHE Ⅱ score and PaO2/FiO2 was analyzed.The area under receiver operating characteristic curve(ROC)(AUC)was used to evaluate the prognostic efficacy of serum ANGPTL4 combined with KL-6 in acute respiratory distress syndrome.Results:Compared with control group,the expression levels of serum ANGPTL4 and KL-6 in observation group were significantly increased(P＜0.05).The expression levels of ANGPTL4 and KL-6 in serum were significantly different among mild,moderate and severe groups(P＜0.05),and the more severe acute respiratory distress syndrome was,the more obvious the increase was.By Pearson correlation analysis,the expression levels of serum ANGPTL4 and KL-6 in patients with acute respiratory distress syndrome were negatively correlated with PaO2/FiO2(P＜0.05),and positively correlated with APACHE Ⅱ score(P＜0.05).ROC curve analysis showed that serum ANGPTL4 combined with KL-6 had a sensitivity of 90.14％,a specificity of65.74％and an AUC of 0.900 in predicting death within 28 days after admission to hospital in patients with acute respiratory distress syndrome.Conclusion:The increase of serum ANGPTL4 and KL-6 expression levels is closely related to the increase of the severity of acute respiratory distress syndrome,the combination of ANGPTL4 and KL-6 has certain value in the prognosis assessment of patients,and can be used as an auxiliary indicator to judge the disease and prognosis.
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