Effect of Warming Needle Moxibustion on Serum CXCR16,CCL19 and TLR4/NF-κB Signaling Pathway in Patients with Rheumatoid Arthritis of Cold Dampness Obstruction Type
Objective:To observe the effect of Needle warming moxibustion on Serum CXCR16,CCL19 and TLR4/NF-κB Signaling Pathway in Patients with Cold dampness obstruction type Rheumatoid Arthritis.Methods:80 RA patients who were admitted to Foshan Jianxiang Bone Injury Hospital from June 2020 to June 2022 were selected.Patients were divided into control group(receiving conventional western medicine treatment,40 cases)and study group(combined with warming needle moxibustion treatment on the basis of control group,40 cases)according to the random number table method.The changes of scores[chinese medicine syndrome scores,28 joint disease activity score(DAS28)],laboratory indexes[rheumatoid factor(RF),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),anti-cyclic citrullinated antibody(anti-CCP antibody)],serum CXCR16,CCL19 and TLR4/NF-κB signaling pathway related indexes were compared between two groups.Results:After treatment,the scores of traditional Chinese medicine syndromes and DAS28 scores decreased in both groups,and the study group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of rheumatoid factor(RF),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and anti cyclic citrulline antibody(anti CCP antibody)decreased in both groups,and the study group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,CXCR16 and CCL19 decreased in both groups,and the study group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,two groups of TLR4mRNA and NF-κ B mRNA decreased and the study group was lower than the control group,the difference was statistically significant(P＜0.05).Conclusion:Needle warming moxibustion can significantly improve the clinical symptoms of RA patients with cold dampness arthralgia,regulate the levels of CXCR16 and CCL19 in serum,and inhibit TLR4NF-KActivation of the B signaling pathway.
Warming needle moxibustionCold dampness obstruction typeRheumatoid arthritisCXCR16CCL19TLR4/NF-κB signal pathway
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