Clinical Value of Transvaginal Color Doppler Ultrasound Combined with lncRNA CCAT1 in the Diagnosis of Epithelial Ovarian Cancer
Objective:To investigate the clinical value of transvaginal color Doppler ultrasound combined with serum long non-coding RNA(lncRNA)colorectal related transcript 1(CCAT1)in the diagnosis of epithelial ovarian cancer.Methods:A total of 88 patients with epithelial ovarian tumors admitted to our hospital from May 2020 to May 2022 were divided into benign group(n=49)and malignant group(n=39)according to the results of pathological examination.Transvaginal color Doppler ultrasonography and lncRNA CCAT1 detection were performed on all subjects.The receiver operating characteristic curve(ROC)was used to evaluate the value of color doppler ultrasound parameters combined with serum lncRNA CCAT1 in the evaluation of epithelial ovarian cancer and its malignancy.Results:The resistance index(RI)and pulsatility index(PI)in the malignant group were lower than those in the benign group,and the peak systolic blood flow velocity(PSV),end diastolic blood flow velocity(EDV)and serum lncRNA CCAT1 levels were higher than those in the benign group(P＜0.05).In the malignant group,RI and PI in patients with Ⅲ-Ⅳ stage were lower than those in patients with Ⅰ-Ⅱ stage,and PSV,EDV and serum lncRNA CCAT1 levels were higher than those in patients with stage Ⅰ-Ⅱ(P＜0.05).ROC analysis showed that the area under the curve(AUC)of RI,PI,PSV,EDV and lncRNA CCAT1 in the combined evaluation of epithelial ovarian cancer was 0.977,and the combined evaluation efficiency was better than that of each index alone.At the same time,the AUC of RI,PI,PSV,EDV and lncRNA CCAT1 combined to evaluate the malignant degree of epithelial ovarian cancer was 0.979,and the combined evaluation efficiency was better than that of each index alone.Conclusion:Transvaginal color Doppler ultrasound combined with serum lncRNA CCAT1 detection has certain evaluation value for epithelial ovarian cancer and its malignancy,and each parameter combined with lncRNA CCAT1 has better evaluation efficiency.
Epithelial ovarian cancerColor Doppler ultrasoundlncRNA CCAT1Diagnostic value
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