Relationship between Serum miR-203a,miR-31-5p,miR-19b-1-5p Levels and Delayed Healing of Fractures in Patients with Femoral Neck Fractures and its Predictive Value Analysis
Objective:To explore the relationship between serum microribonucleic acid(miR)-203a,miR-31-5p,miR-19b-1-5p levels and delayed healing of fractures after operation in patients with femoral neck fractures and its predictive value for delayed healing of fractures after operation.Methods:292 patients with fresh femoral neck fractures who were underwent internal fixation treatment at Affiliated Hospital of Xuzhou Medical University from January 2020 to October 2022 were selected as research subjects.At the followed up examination 4 weeks after operation,the patient's serum miR-203a,miR-31-5p,and miR-19b-l-5p levels were detected,and patients were divided into delayed group(n=36)and healing group(n=256)according to their fractures healing status.The influencing factors of delayed healing of fractures after operation in patients with femoral neck fractures was analyzed by the multivariate Logistic regression.The predictive value of serum miR-203a,miR-31-5p,and miR-19b-l-5p for delayed healing of fractures after operation in patients with femoral neck fractures was analyzed by the receiver operating characteristic(ROC)curve.Results:At the followed up examination 4 months after operation,and the incidence of delayed healing of fractures was 12.33％.There were significant differences in age,smoking history and combined with diabetes between two groups(P＜0.05).The serum miR-203a,miR-3 1-5p,and miR-19b-1-5p levels in healing group were higher than those in delayed group(P＜0.05).Multivariate Logistic regression analysis showed that age greater than or equal to 60 years old,combined with diabetes,reduced levels of serum miR-203a,miR-3 1-5p,miR-19b-l-5p were independent risk factors for delayed healing of fractures after operation in patients with femoral neck fractures(P＜0.05).ROC results showed that the area under the curve(AUC)(0.95CI)of the three indicators joint detected was 0.841(0.738～0.936),which was higher than the AUC when each indicator was applied separately,and the sensitivity and specificity of the three indicators joint detection were also higher than those of single indicator detected.Conclusion:Serum miR-203a,miR-3 1-5p,and miR-19b-1-5p are low expressed in patients with delayed healing of fractures after operation of femoral neck fractures,which are independent risk factors for delayed healing of fractures,and the three indicators joint detection has high predictive value for delayed healing of fractures in patients with femoral neck fractures.
Femoral neck fracturesDelayed healingMiR-203aMiR-31-5pMiR-19b-1-5pPredictive value
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