The Expression Significance of Serum PSA and EGF in Patients with Different Types of Benign Prostatic Hyperplasia and Their Correlation with Postoperative Disease Outcome
Objective:To analyze the significance of low expression of serum prostate-specific antigen(PSA)and epidermal growth factor(EGF)in patients with different types of benign prostatic hyperplasia(BPH)and their correlation with postoperative disease outcomes.Methods:128 patients with benign prostatic hyperplasia who received surgical treatment in our hospital from January 2020 to December 2022 were selected as the study objects and grouped according to postoperative pathological biopsy results.Interstitial nodule group(16 cases),adenomuscular nodule group(32 cases),fibladenomatous nodule group(12 cases),glandular nodule group(30 cases)and mixed nodule group(38 cases),of which 60 cases had interstitial hyperplasia and 68 cases had glandular hyperplasia.The expression levels of serum PSA and EGF in all patients were detected,and the International Prostate Symptom score(IPSS)＜8 six months after surgery was used to determine the prognosis.The difference between serum PSA and EGF in the good prognosis group and the poor prognosis group and the relationship with IPSS score were analyzed.Results:There were differences in serum PSA and EGF expression levels among interstitial nodule group,adenomuscular nodule group,fibladenoma nodule group,glandular nodule group and mixed nodule group(P＜0.05).The serum levels of PSA and EGF in BPH patients with glandular hyperplasia were significantly higher than those in BPH patients with interstitial hyperplasia(P＜0.05).ROC curve analysis showed that serum PSA combined with EGF had a sensitivity of 86.42％,specificity of 65.34％and AUC of 0.930 in predicting benign prostatic hyperplasia(BPH).All patients were followed up for 6 months,with good prognosis in 98 cases and bad prognosis in 30 cases.The expression levels of serum PSA and EGF in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).According to Pearson correlation analysis,serum PSA and EGF expression levels in BPH patients were negatively correlated with IPSS score(r value was-0.348,-0.417,P value was 0.000).Conclusion:Serum PSA and EGF are significantly different in patients with different pathologic types of BPH,and the serum PSA and EGF are higher in patients with mainly interstitial hyperplasia and mainly glandular hyperplasia,both of which are closely related to postoperative disease outcomes and deserve clinical attention.
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