Application Value of Omalizumab on Patients with Allergic Rhinitis Based on Changes of Serum IgE Level and Olfactory Function
Objective:To explore the application value of omalizumab on patients with allergic rhinitis based on changes of serum IgE level and olfactory function.Methods:80 patients with allergic rhinitis admitted to our hospital from January 2021 to December 2022 were selected and randomly divided into observation group(omalizumab treatment,40 cases)and control group(conventional drug treatment,40 cases)according to the odd-even number method.The clinical efficacy after 3 months of treatment and adverse reactions(epistaxis,oropharyngeal dryness,nasal dryness)during treatment,immune function(serum IgE,CD3+,CD4+,CD8+),nasal endoscopy results(inflammatory exudation,edema,vesicles),olfactory function change and quality of life[Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)]before treatment and after 3 months of treatment were compared between the two groups.Results:The clinical efficacy in observation group was significantly higher than that in control group after 3 months of treatment(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).After 3 months of treatment,IgE,CD8+,nasal endoscopy results and RQLQ score in both groups were significantly reduced compared with those before treatment,and the above indicators in observation group were significantly lower than those in control group(all P＜0.05).The levels of CD3+and CD4+and olfactory function in both groups were significantly higher than those before treatment,and the indicators were significantly higher in observation group(all P＜0.05).Conclusion:Omalizumab can effectively relieve the symptoms,improve the immune function,and significantly enhance the olfactory function of patients,and it has good safety and has a positive impact on the quality of life of patients.
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