The Changes of Serum BALP,OPG/PYR Ratio and Their Correlation with Bone Mineral Density and Fracture in Elderly Patients with Different Degrees of Osteoporosis
Objective:To analyze the changes of serum bone-specific alkaline phosphatase(BALP),osteopontin(OPG)/Pyridinoline(PYR)ratio and their correlation with bone mineral density and fracture in elderly patients with different degrees of osteoporosis.Methods:A total of 70 elderly patients with osteoporosis admitted to our hospital from November 2020 to July 2023 were selected as the observation group,including 44 cases with mild to moderate osteoporosis and 26 cases with severe osteoporosis.Another 70 non-osteoporosis elderly patients were selected as control group.Serum BALP,OPG/PYR ratio,bone mineral density(BMD)of lumbar spine,femoral neck and hip were measured in all subjects.The relationship between BALP,OPG/PYR ratio and BMD of different bone parts was analyzed.The predictive efficacy of BALP and OPG/PYR ratio in elderly osteoporotic fractures was analyzed using receiver operating characteristic(ROC)curve.Results:The serum BALP level in the observation group was higher than that in the control group,and the OPG/PYR ratio was lower than that in the control group(P＜0.05).The serum BALP level in severe osteoporosis group was higher than that in mild-moderate osteoporosis group,and the OPG/PYR ratio was lower than that in mild-moderate osteoporosis group(P＜0.05).The BMD of lumbar spine,femoral neck and hip in observation group was lower than that of control group(P＜0.05).By Pearson correlation analysis,BMD of lumbar spine,femoral neck and hip was negatively correlated with serum BALP level(P＜0.05),and positively correlated with OPG/PYR ratio(P＜0.05).According to ROC curve analysis,serum BALP combined with OPG/PYR ratio predicted the AUC of osteoporotic fracture in elderly patients was 0.890.Conclusion:The increase of serum BALP level and the decrease of OPG/PYR ratio in elderly patients with osteoporosis are related to the severity of the disease and bone mineral density,and the combined prediction of fracture is good,worthy of further study and application.
Old ageOsteoporosisBone specific alkaline phosphataseOsteoprotectinPyridinoline
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