Expression of Adenosine Deaminase Acting on RNA 1 in Gastric Cancer and its Clinical Significance
Objective:In this study,we aimed to observe the expression of ADAR1 in gastric cancer patients and to determine the role of ADAR1 and underlying the potential clinical significance of ADAR1 in gastric cancer.Methods:Through the GEPIA database,we found differences in the expression of ADAR1 at the mRNA level between gastric cancer and normal gastric tissue samples.In the gastric cancer and paired tissues of 170 gastric cancer patients collected at Xijing Hospital,we verified this difference through immuno-histochemistry and analyzed the relationship between the expression of AD ARI and pathological features.Through the Kaplan-Meier Plotter platform and the TCGA database,we analyzed the impact of ADAR1 expression on the prognosis of gastric cancer patients.Results:ADAR1 was abnormally high expressed in gastric cancer.Moreover,the results showed that the high expression of ADAR1 was related to histological differentiation of gastric cancer(P=0.044).Gender(HR=2.082 95％CI=1.160-3.736,P=0.014),and lymph node enlargement(HR=1.582,95％CI=1.003-2.496,P=0.049),which were independent risk factors affecting the overall survival of gastric cancer patients.We also found that the expression of ADAR1 was positively correlated with tumor mutation burden(TMB)(P=0.002),indicating potential value in assessing the immunotherapeutic value of gastric cancer patients.In addition,patients with high expression of ADAR1 had a shorter overall survival and poor prognosis.Conclusions:The high expression of ADAR1 in gastric cancer may have the potential to judge prognosis and assess the value of immunotherapy,and is expected to become a new clinical diagnostic and thera-peutic target.
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