Relationship between the Expression of LncRNA DLEU 1 and LncRNA NONHSAT017458 in Colon Cancer Tissues and Clinicopathological Features and Prognosis
Objective:To investigate the relationship between the expression of long-chain non-coding ribonucleic acid(LncRNA)lymphocytic leukemia deletion gene 1(DLEU1)and LncRNA NONHSAT017458 in colon cancer tissues and clinicopathological features and prognosis.Methods:136 colon cancer patients who were admitted to our hospital from March 2020 to December 2022 were selected,the expression of LncRNA DLEU1 and LncRNA NONHSAT0 17458 was detected in surgically resected cancer tissues and cancer adjacent tissues(more than 5 cm from the cancer adjacent tissues).The expression differences of LncRNA DLEU1 and LncRNA NONHSAT017458 in colon cancer tissues with different pathological features were compared,the survival rate of colon cancer patients with different LncRNA DLEU1 and LncRNA NONHSAT017458 expression were analyzed by Kaplan-Meier survival curve,the difference of survival rate were tested by Log-Rank test,the factors affecting the survival of colon cancer patients were analyzed by univariate and multivariate Cox risk proportional regression analysis.Results:The expression of LncRNA DLEU1 and LncRNA NONHSATO 17458 in cancer tissues was higher than that in cancer adjacent tissues,and the difference was statistically significant(P＜0.05).The expression of LncRNA DLEU1 and LncRNA NONHSATO 17458 in cancer tissues with tumor diameter ≥4 cm,low differentiation,T34 and N1-2 was higher than that in tumor diameter＜4 cm,medium and high differentiation,T1.2 and No,and the difference was statistically significant(P＜0.05).The 3-year overall survival(OS)rate and 3-year progression-free survival(PFS)in colon cancer patients with high expression of LncRNA DLEU1 and LncRNA NONHSAT017458 were lower than those in colon cancer patients with low expression of LncRNA DLEU1 and LncRNA NONHSAT017458,and the differences were statistically significant(P＜0.05).Multivariate Cox regression analysis showed that high T stage,high N stage,high LncRNA DLEU1 expression,and high LncRNA NONHSAT017458 expression were risk factors for poor prognosis in colon cancer patients(P＜0.05).Conclusion:The expression of LncRNA DLEU1 and LncRNA NONHSAT017458 is up-regulate in colon cancer tissues,the high level of expression is relate to the high T,N stage and poor differentiation of colon cancer,which can lead to adverse outcomes in patients.
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