Study on the Relationship between Serum Irisin,MBL and Inflammatory Factors and Arteriovenous Fistula Thrombosis in Maintenance Hemodialysis Patients
Objective:To investigate the relationship between serum Irisin,mannose-binding lectin(MBL)and inflammatory fac-tors and arteriovenous fistula(AVF)thrombosis in maintenance hemodialysis(MHD)patients.Methods:125 MHD patients who were admitted to Shijiazhuang People's Hospital from January 2021 to October 2022 were selected as MHD group,patients were divided into thrombosis group(41 cases)and non-thrombosis group(84 cases)according to the presence or absence of thrombosis,and 85 healthy people who underwent physical examination in our hospital during the same period were selected as control group.The levels of serum Irisin,MBL and inflammatory factors[interleukin(IL)-1 β,IL-6,tumor necrosis factor-a(TNF-α)]were detected by enzyme-linked im-munosorbent assay.The correlation between serum Irisin,MBL and inflammatory factors in MHD patients were analyzed by Spearman correlation,the influencing factors of AVF thrombosis in MHD patients were analyzed by multivariate Logistic regression,the predictive efficacy of serum Irisin and MBL on AVF thrombosis in MHD patients were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with control group,the serum Irisin level in the MHD group was decreased,and the levels of MBL,IL-1 β,IL-6 and TNF-α were increased(P＜0.05).Spearman correlation analysis showed that,serum Irisin was negatively correlated with IL-1β,IL-6 and TNF-α levels in MHD patients,and MBL was positively correlated with IL-lβ,IL-6 and TNF-α levels(P＜0.05).Multivariate logistic re-gression analysis showed that the prolonged dialysis age was extendedand,the increased platelet count,D-dimer,TNF-α,and MBL were independent risk factors for AVF thrombosis in MHD patients,and increased Irisin was an independent protective factor(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum Irisin and MBL combined to predict AVF thrombosis in MHD pa-tients was 0.826,which was greater than that predicted by a single index.Conclusion:The decrease of serum Irisin level and the increase of MBL in MHD patients were relate to the increase of inflammatory factors and AVF thrombosis,the combination of serum Irisin and MBL had a higher predictive efficiency for AVF thrombosis in MHD patients.
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