摘要
目的:探讨高分辨率超声联合血清同型半胱氨酸(HCY)、生长分化因子15(GDF-15)、神经胶质纤维酸性蛋白(GFAP)对缺血性脑梗死的诊断价值.方法:选择2021年3月-2023年3月本院收治的162例缺血性脑梗死患者作为梗死组,另选取同期138名健康体检者作为对照组,所有受试者均行高分辨率超声技术测量颈动脉内膜/中膜厚度(cIT/cMT)和桡动脉内膜/中膜厚度(rIT/rMT),所有受试者均行酶联免疫吸附试验法(ELISA)测定其血清HCY、GDF-15、GFAP水平,比较两组之间各测量参数的差异.通过绘制受试者工作特征曲线(ROC)分析高分辨率超声参数、血清HCY、GDF-15、GFAP水平对缺血性脑梗死的诊断效能.结果:梗死组cIT、rIT、血清HCY、GDF-15、GFAP水平显著高于对照组(P＜0.05);而两组cMT、rMT差异无统计学意义(P＞0.05).与单独诊断相比较,高分辨率超声参数cIT、rIT联合血清HCY、GDF-15、GFAP水平对缺血性脑梗死评估的曲线下面积(AUC)、约登指数、敏感度、特异度最高.结论:高分辨率超声参数cIT、rIT联合血清HCY、GDF-15、GFAP水平对缺血性脑梗死具有更高的诊断价值,有助于指导临床对缺血性脑梗死患者的诊断.
Abstract
Objective:To evaluate the diagnostic value of high resolution ultrasound combined with serum homocysteine(HCY),growth differentiation factor 15(GDF-15)and glial fibrillary acidic protein(GFAP)in ischemic cerebral infarction.Methods:162 patients with ischemic stroke admitted to our hospital from March 2021 to March 2023 were selected as the infarction group,and 138 healthy in-dividuals during the same period were selected as the control group.All subjects underwent high-resolution ultrasound technology to measure carotid artery intima/media thickness(cIT/cMT)and radial artery intima/media thickness(rIT/rMT),and their serum HCY,GDF-15,and GFAP levels were measured using enzyme-linked immunosorbent assay(ELISA),Compared the differences in measure-ment parameters between two groups.Analyze the diagnostic efficacy of high-resolution ultrasound parameters,serum HCY,GDF-15,and GFAP levels for ischemic stroke by drawing receiver operating characteristic(ROC)curves.Results:The levels of cIT,rIT,serum HCY,GDF-15 and GFAP in infarction group were significantly higher than those in control group(P＜0.05).There was no significant difference in cMT and rMT between the two groups(P＞0.05).Compared with diagnosis alone,high resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels had the highest area under the curve(AUC),Yoden index,sensitivity and specificity in the evaluation of ischemic cerebral infarction.Conclusion:High resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels have higher diagnostic value for ischemic cerebral infarction,which is helpful to guide the clinical diagnosis of patients with ischemic cerebral infarction.
基金项目
北京市卫生计生委首都卫生发展科研专项(2018-3-7083)
NETL
NSTL
万方数据