Diagnostic Value of High Resolution Ultrasound Combined with Serum HCY,GDF-15 and GFAP in Ischemic Cerebral Infarction
Objective:To evaluate the diagnostic value of high resolution ultrasound combined with serum homocysteine(HCY),growth differentiation factor 15(GDF-15)and glial fibrillary acidic protein(GFAP)in ischemic cerebral infarction.Methods:162 patients with ischemic stroke admitted to our hospital from March 2021 to March 2023 were selected as the infarction group,and 138 healthy in-dividuals during the same period were selected as the control group.All subjects underwent high-resolution ultrasound technology to measure carotid artery intima/media thickness(cIT/cMT)and radial artery intima/media thickness(rIT/rMT),and their serum HCY,GDF-15,and GFAP levels were measured using enzyme-linked immunosorbent assay(ELISA),Compared the differences in measure-ment parameters between two groups.Analyze the diagnostic efficacy of high-resolution ultrasound parameters,serum HCY,GDF-15,and GFAP levels for ischemic stroke by drawing receiver operating characteristic(ROC)curves.Results:The levels of cIT,rIT,serum HCY,GDF-15 and GFAP in infarction group were significantly higher than those in control group(P＜0.05).There was no significant difference in cMT and rMT between the two groups(P＞0.05).Compared with diagnosis alone,high resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels had the highest area under the curve(AUC),Yoden index,sensitivity and specificity in the evaluation of ischemic cerebral infarction.Conclusion:High resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels have higher diagnostic value for ischemic cerebral infarction,which is helpful to guide the clinical diagnosis of patients with ischemic cerebral infarction.
High resolution ultrasoundHCYGDF-15GFAPIschemic cerebral infarctionDiagnostic value
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