Effects of Hyperbaric Oxygen Therapy at Different Time Windows on Serum ZO-1,Caveolin-1 and TLR4/NF-κB Signaling Pathway in Patients with Acute Cerebral Infarction
Objective:To investigate the effects of hyperbaric oxygen therapy at different time windows on serum tight junction protein(ZO-1),caveolin-1(Caveolin-1)and Toll-like receptor 4(TLR4)/nuclear transcription factor-KB(NF-κB)signaling pathway in patients with acute cerebral infarction(ACI).Methods:158 ACI patients who were treated in The First Affiliated Hospital of Air Force Military Medical University from April 2020 to April 2023 were selected as the research objects,patients were divided into group A(ac-cept routine treatment,hyperbaric oxygen therapy was given within 12 h～7 d after the onset of the disease)and group B(accept routine treatment,hyperbaric oxygen therapy was performed within 12 h onset)by random number table method,with 79 cases in each group.The changes of each scale score,cerebral blood perfusion,serum ZO-1,Caveolin-1 levels and TLR4/NF-κB signaling pathway related in-dicators were compared in two groups.Results:After treatment,the National Institutes of Health Stroke Scale(NIHSS)in group B was lower than that in group A,and the activity of daily living(ADL)score was higher than that in group A(P＜0.05).After treatment,the cerebral vascular reserve capacity(CVR),bilateral cerebral artery peak flow velocity and bilateral cerebral artery peak average flow ve-locity in group B were higher than those in group A(P＜0.05).After treatment,serum Caveolin-1 in group B was lower than that in group A,and serum ZO-1 was higher than that in group A(P＜0.05).After treatment,TLR4 and NF-κB in group B were lower than those in group A(P＜0.05).Conclusion:Hyperbaric oxygen therapy in ACI patients within 12 hours of onset can effectively promote the recovery of neurological function and regulate the levels of serum ZO-1 and Caveolin-1,which may be relate to the inhibition of TLR4/NF-κB sig-naling pathway activation.
Time windowHyperbaric oxygenAcute cerebral infarctionZO-1Caveolin-1TLR4/NF-κB signaling pathway
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