Study on the Relationship between Serum IL-1 β,FABP4,STRA6 and Type 2 Diabetes Mellitus Combined with Dry Eye Disease
Objective:To investigate the relationship between serum interleukin-1β(IL-1β),fatty acid binding protein 4(FABP4),stimulated by retinoic acid 6(STRA6)and type 2 diabetes mellitus(T2DM)combined with dry eye disease(DED).Methods:129 patients with T2DM combine with DED(T2DM combine with DED group),117 patients with simple T2DM(simple T2DM group)and 85 healthy volunteers(control group)admitted to The Fourth Affiliated Hospital of Nanjing Medical University from June 2020 to June 2023 were selected,patients with T2DM combine with DED were divided into mild group(61 cases),moderate group(36 cases)and se-vere group(32 cases)according to the severity of DED.The levels of serum IL-1 β,FABP4 and STRA6 were detected by enzyme-linked immunosorbent assay.The influencing factors of T2DM combine with DED were analyzed by multivariate logistic regression analysis,and the predictive value of serum IL-1β,FABP4 and STRA6 levels for T2DM combine with DED were analyzed by ROC curve.Results:The levels of serum IL-1β,FABP4 and STRA6 in T2DM combine with DED group were higher than those in simple T2DM group and control group,and the levels of serum IL-1β,FABP4 and STRA6 in simple T2DM group were higher than those in control group(P＜0.05).The levels of serum IL-lβ,FABP4 and STRA6 in severe group were higher than those in moderate group and mild group,and the levels of serum IL-1 β,FABP4 and STRA6 in moderate group were higher than those in mild group(P＜0.05).Multivariate logistic regres-sion analysis showed that prolonged course of T2DM and elevated glycated hemoglobin,IL-1β,FABP4,and STRA6 were independent risk factors for T2DM combine with DED,and elevated BUT was an independent protective factor(P＜0.05).The area under the curve of combined prediction of serum IL-1β,FABP4 and STRA6 levels for T2DM combine with DED was 0.916,which was greater than 0.784,0.782 and 0.788 predicted by serum IL-1β,FABP4 and STRA6 levels alone.Conclusions:The levels of serum IL-1β,FABP4 and STRA6 in patients with T2DM combined with DED are increase,which are independent risk factors for T2DM combine with DED,and are relate to the severity of DED.The combined detection of serum IL-1β,FABP4 and STRA6 has a higher predictive value for T2DM combine with DED.
Type 2 diabetes mellitusIL-1βFABP4STRA6Dry eye disease
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NSTL
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