Effects of Shenyan Kangfu Tablets Combined with Piperazine Ferulate on Renal Function,Inflammatory Factors and Oxidative Stress in Patients with Chronic Glomerulonephritis
Objective:To investigate the effects of shenyan kangfu tablets combined with piperazine ferulate on renal function,in-flammatory factors and oxidative stress in patients with chronic glomerulonephritis.Methods:110 patients with chronic glomerulonephri-tis admitted to The First Affiliated Hospital of Xi'an Jiaotong University from April 2021 to December 2022 were divided into control group(n=55,treated with piperazine ferulate)and observation group(n=55,on the basis of the control group receiving treatment with nephritis rehabilitation tablets)according to the random number table method.The efficacy,renal function indexes[urea nitrogen(BUN),serum creatinine(Scr),24 h urine protein quantification(24hUPR),urine red blood cell(RBC)],inflammatory factor indexes[inter-leukin-lβ(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)],oxidative stress indexes[glutathione peroxidase(GSH-PX),superoxide dismutase(SOD),malondialdehyde(MDA)]and adverse reactions were compared between two groups.Results:The total clinical effective rate in observation group was higher than that in control group(P＜0.05).BUN,Scr,24hUPR and urine RBC in observa-tion group were lower than those in control group 2 courses after treatment(P＜0.05).MDA was lower than that in control group 2 courses after treatment,GSH-PX and SOD in observation group were higher than those in control group(P＜0.05).IL-lβ,TNF-α and IL-17 in observation group were lower than those in control group 2 courses after treatment(P＜0.05).There were no obvious adverse reactions in two groups(P＞0.05).Conclusion:Shenyan kangfu tablets combined with piperazine ferulate in the treatment of patients with chronic glomerulonephritis,which can effectively improve the renal function and oxidative stress of patients,and reduce the level of inflammatory factors.
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