Study on the Value of Uterine Artery Blood Flow Parameters Combined with Serum β-HCG,P and E2 in Predicting Abortion in Pregnant Women with Recurrent Spontaneous Abortion Re-Pregnancy
Objective:To investigate the value of uterine artery blood flow parameters[pulsation index(PI),resistance index(RI),systolic/diastolic blood flow velocity(S/D)]combine with serum β-human chorionic gonadotropin(β-HCG),progesterone(P)and estra-diol(E2)in predicting abortion in pregnant women with recurrent spontaneous abortion(RSA)re-pregnancy.Methods:145 pregnant women with RS A re-pregnancy(RSA group)who were admitted to Anhui Maternal and Child Health Hospital from January 2021 to Oc-tober 2022 were selected,and 145 healthy pregnant women(control group)in our hospital during the same period were selected,preg-nant women with RSA re-pregnancy were divided into abortion group(65 cases)and live birth group(80 cases)according to the preg-nancy outcome.The levels of serum β-HCG,P and E2 were detected,and the uterine artery blood flow parameters were detected by transvaginal ultrasound.The factors affecting of abortion in pregnant women with RSA re-pregnancy were analyzed by multivariate Lo-gistic regression analysis,the value of uterine artery blood flow parameters combined with serum β-HCG,P and E2 in predicting abortion in pregnant women with RSA re-pregnancy were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of PI,RI and S/D in RSA group were higher than those in control group,and the levels of serum β-HCG,P and E2 were lower than those in control group(P＜0.05).PI,RI and S/D in abortion group were higher than those in live birth group,and serum β-HCG,P and E2 levels were lower than those in live birth group(P＜0.05).Multivariate logistic regression analysis showed that increased age,PI,RI,and S/D were indepen-dent risk factors for abortion in pregnant women with RSA re-pregnancy,and increased β-HCG,P,and E2 were independent protective factors(P＜0.05).The area under the curve of uterine artery blood flow parameters combined with serum β-HCG,P and E2 to predict abor-tion in pregnant women with RSA re-pregnancy was 0.941,which was higher than that predicted by single index(P＜0.05).Conclusions:The increase of PI,RI and S/D and the decrease of serum β-HCG,P and E2 in pregnant women with RSA re-pregnancy are closely relate to the occurrence of abortion.Uterine artery blood flow parameters combine with serum β-HCG,P and E2 have a higher predictive value for abortion in pregnant women with RSA.
NETL
NSTL
万方数据
