Study on the Relationship between Serum CyPA,sCLU,HO-1 and Brain Injury after Neonatal Asphyxia Resuscitation
Objective:To investigate the relationship between serum cyclophilin A(CyPA),clusterin(sCLU),heme oxygenase-1(HO-1)and brain injury after neonatal asphyxia resuscitation.Methods:172 asphyxiated neonates who were admitted to Minda Hospital Affiliated to Hubei Minzu University from June 2020 to March 2023 were selected,patients were divided into brain injury group(80 cases)and non-brain injury group(92 cases)according to whether brain injury occurred after resuscitation,the levels of serum CyPA,sCLU and HO-1 were detected and compared between two groups before resuscitation.The influencing factors of brain injury after neonatal asphyxia resuscitation were analyzed by multivariate Logistic regression,the value of serum CyPA,sCLU and HO-1 in predicting brain injury after neonatal asphyxia resuscitation were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum CyPA,sCLU and HO-1 in brain injury group were higher than those in non-brain injury group(P＜0.05).Placental abruption,maternal pregnancy-induced hypertension,severe asphyxia,high level of CyPA,high level of sCLU and high level of HO-1 were risk factors for brain injury after neonatal asphyxia resuscitation(P＜0.05).The area under the curve of serum CyPA,sCLU and HO-1 in predicting brain injury after neonatal asphyxia resuscitation was 0.797,0.832 and 0.779 respectively.The area under the curve of combined prediction was 0.941,which was higher than that of each index alone.Conclusion:The risk factors for brain injury after neonatal asphyxia resuscita-tion include placental abruption,maternal pregnancy-induced hypertension,severe asphyxia,increased CyPA,increased sCLU,and increased HO-1,combine detection of serum CyPA,sCLU and HO-1 has a high predictive value for brain injury after neonatal asphyxia resuscitation.
Neonatal asphyxiaBrain injuryCyPAsCLUHO-1Predictive value
NETL
NSTL
万方数据
