Value of Serum S100A2 Combined with S100A11 in Predicting Ventilator Associated Pneumonia in AECOPD Patients and its Relationship with Prognosis
Objective:To investigate the value of serum S100 calcium binding protein A2(S100A2)combined with S100A11 in predicting ventilator associated pneumonia(VAP)in patients with acute exacerbation of chronic obstructive pulmonary disease(AE-COPD)and its relationship with prognosis.Methods:175 AECOPD patients admitted to Taizhou Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2021 to January 2022 were selected,patients were divided into non VAP group and VAP group according to the occurrence of VAP,and AECOPD patients complicated with VAP were divided into death group and survival group according to the 28 days survival situation.Serum S100A2 and S100A11 levels were detected by enzyme linked immunosorbent assay.The influencing factors of VAP in AECOPD patients were analyzed by multivariate Logistic regression analysis,the value of serum S100A2 combined with S100A11 in predicting VAP in AECOPD patients and predicting the value of death in AECOPD patients with VAP were analyzed by receiver operating characteristic(ROC)curve.Results:The incidence of VAP in 175 AECOPD patients was 41.14％.The levels of serum S100A2 and S100A11 in VAP group were higher than those in non VAP group(P＜0.05).Multivariate Lo-gistic regression analysis showed that,prolonged COPD course,increased clinical pulmonary infection score(CPIS),mechanical ventila-tion time＞4 d,re-intubation after admission and increased S100A2 and S100A11 were independent risk factors for VAP in AECOPD patients(P＜0.05).The 28 days mortality rate of 72 AECOPD patients complicated with VAP was 19.44％.Compared with survival group,the serum levels of S100A2 and S100A11 in death group were increased(P＜0.05).The area under the curve(AUC)of serum S100A2 combined with S100A11 for predicting VAP in AECOPD patients was 0.858.The AUC of serum S100A2 combined with S100A11 in predicting the death of patients with AECOPD complicated with VAP was 0.798.The value of serum S100A2 combined with S100A11 in predicting the occurrence of VAP in AECOPD patients and predicting the death of AECOPD patients complicated with VAP was greater than that of each index alone.Conclusion:Elevated serum S100A2 and S100A11 levels are associated with VAP and poor prognosis in AECOPD patients,and the value of serum S100A2 combine with S100A11 in predicting VAP and poor prognosis in AECOPD patients is high.
Acute exacerbation of chronic obstructive pulmonary diseaseS100A2S100A11Ventilator associated pneumoniaPrognosis
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