摘要
目的:探讨集体语言训练联合经颅直流电刺激(tDCS)对语言发育迟缓患儿发育水平、言语功能及神经中枢营养因子水平的影响.方法:采用信封抽签法将郴州市第一人民医院2021年2月到2023年2月期间收治的90例语言发育迟缓患儿分为对照组(n=45,常规语言训练联合tDCS)和研究组(n=45,集体语言训练联合tDCS).对比两组疗效、发育水平、言语功能、神经中枢营养因子及生活质量.结果:与对照组相比,研究组的临床总有效率更高(P＜0.05).两组干预后动作能、应物能、言语能、应人能评分均升高,且研究组高于对照组(P＜0.05).两组干预后复述、听理解、口头表达、出声读、抄写、阅读、描写、听写以及计算评分均升高,且研究组高于对照组(P＜0.05).两组干预后血清脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)、神经生长因子(NGF)、神经营养因子-3(NT-3)较干预前升高(P＜0.05).两组干预后血清BDNF、NGF、GDNF、NT-3组间对比未见差异(P＞0.05).两组干预后生理功能、社会功能、情感功能、角色功能评分升高,且研究组高于对照组(P＜0.05).结论:集体语言训练联合tDCS干预语言发育迟缓患儿,可改善言语功能和神经功能,提高其发育水平和生活质量.
Abstract
Objective:To investigate the effects of collective language training combined with transcranial direct current stimula-tion(tDCS)on development level,speech function and nerve central nutrition factor level in children with language development delay.Methods:90 children with language retardation admitted to Chenzhou First People's Hospital from February 2021 to February 2023 were divided into a control group(n=45,conventional language training combined with tDCS)and a research group(n=45,collective language training combined with tDCS)by envelope lottery.The efficacy,development level,speech function,nerve central nutrition factor and quality of life were compared between two groups.Results:Compared with control group,the total clinical effective rate in study group was higher(P＜0.05).The scores of motor behavior,adaptive behavior,language behavior and personalsocial behavior in two groups in-creased after intervention,and those in study group were higher than control group(P＜0.05).The scores of retelling,listening comprehen-sion,oral expression,aloud reading,copying,reading,description,dictation and calculation in two groups increased after intervention,and those in study group were higher than control group(P＜0.05).The serum levels of brain-derived neurotrophic factor(BDNF),glial cell line-derived neurotrophic factor(GDNF),nerve growth factor(NGF)and neurotrophic factor-3(NT-3)in two groups after interven-tion were higher than those before intervention(P＜0.05).There was no difference in serum BDNF,NGF,GDNF and NT-3 between two groups after intervention(P＞0.05).The scores of physiological function,social function,emotional function and role function in two groups increased after intervention,and those in study group were higher than control group(P＜0.05).Conclusion:Collective language training combine with tDCS intervention in children with language development delay,which can improve speech function and neurolog-ical function,and improve their development level and quality of life.
基金项目
湖南省自然科学基金(2019BJ40010)
郴州市第一人民医院院级科研项目(N2020-39)
NETL
NSTL
万方数据