Evaluation Value of Tuberculosis Infection T Cell Spot Test Combined with Serum ADA,SAA and CA125 in the Diagnosis and Treatment Outcome of Active Pulmonary Tuberculosis
Objective:To investigate the evaluation value of tuberculosis infection T cell spot test(T-SPOT.TB)combined with serum adenosine deaminase(ADA),amyloid A(SAA)and carbohydrate antigen 125(CA125)in the diagnosis and treatment outcome of active pulmonary tuberculosis(APTB).Methods:137 APTB patients(APTB group)and 80 non-APTB patients(control group)who were admitted to Hunan Chest Hospital from October 2021 to October 2022 were selected,all APTB patients received routine anti-tuberculosis treatment,patients were divided into outcome group(92 cases)and non-outcome group(45 cases)according to the treatment outcome.T-SPOT.TB was performed,and serum ADA,SAA and CA125 levels were detected before treatment.The efficacy of T-SPOT.TB com-bined with serum ADA,SAA and CA125 in the diagnosis of APTB and predicting treatment outcome were analyzed by receiver operat-ing characteristic(ROC)curve.Results:The positive rate of T-SPOT.TB and the levels of serum ADA,SAA and CA125 in APTB group were higher than those in control group(P＜0.05).The positive rate of T-SPOT.TB and the levels of serum ADA,SAA and CA125 in non-outcome group were higher than those in outcome group(P＜0.05).The area under the curve(AUC)of T-SPOT.TB combined with serum ADA,SAA and CA125 in diagnosing APTB and predicting its treatment outcome were 0.917 and 0.833 respectively,which were higher than those of single index.Conclusion:The positive rate of T-SPOT.TB in APTB patients increased,and the levels of serum ADA,SAA and CA125 increased,which were relate to the poor prognosis after anti-tuberculosis treatment,T-SPOT.TB combined with serum ADA,SAA and CA125 had high value in the diagnosis and treatment outcome evaluation of APTB.
Tuberculosis infection T cell spot testADASAACA125Active pulmonary tuberculosisDiagnosisTreatment outcome
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