Effect of Biejiajian Pills Combined with Apatinib on Th17/Treg Balance,Apoptotic Molecules and Angiogenesis Factors in Patients with Middle and Late Liver Cancer after TACE
Objective:To observe the effect of biejiajian pills combined with apatinib on helper T cell 17(Th17)/regulatory T cell(Treg)balance,apoptotic molecules and angiogenesis factors in patients with middle and late liver cancer after transcatheter arterial chemoembolization(TACE).Methods:118 patients with middle and late liver cancer admitted to The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from January 2021 to December 2022 were selected,patients received TACE and were divid-ed into control group(59cases,received apatinib)and study group(59cases,biejiajian pills combined with apatinib)according to the ran-dom number table method.The efficacy,serum tumor markers[alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),alpha-fetopro-tein-L3(AFP-L3)],peripheral blood Th17/Treg balance[Th17 cell ratio,Treg cell ratio,Th17/Treg ratio],apoptotic molecules[B-cell lymphoma-2 associated X protein(Bax),cysteine aspartic protease-4(Caspase-4),cysteine aspartic protease-10(Caspase10),B-cell lym-phoma-2 gene(Bcl-2)]and angiogenesis factors[angiopoietin-2(Ang-2),vascular endothelial growth factor(VEGF)]were compared be-tween two groups.Results:The total clinical effective rate in study group was higher than that in control group(P＜0.05).Compared with the control group,the levels of AFP,CEA,AFP-L3,Th17 cell ratio,Thl7/Treg ratio,Bcl-2,Ang-2 and VEGF were lower in the study group,and Treg cell ratio,Bax,Caspase-4,and Caspase-10 were higher after treatment(P＜0.05).There was no difference in the inci-dence of adverse reactions between two groups(P＞0.05).Conclusion:Biejiajian pills combined with apatinib in the treatment of patients with middle and late liver cancer after TACE,which can effectively prevent the progression of the disease,reduce the level of serum tumor markers,and may be relate to the regulation of Th17/Treg balance,apoptotic molecules and angiogenesis factors.
Biejiajian pillsApatinibMiddle and late liver cancerTranscatheter arterial chemoembolizationTh17/Treg balanceApoptotic moleculesAngiogenesis factors
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