Study on the Relationship between Serum 25(OH)D,MCP-1 and Mild Cognitive Impairment in Patients with Hashimoto's Thyroiditis with Normal Thyroid Function
Objective:To investigate the relationship between serum 25 hydroxyvitamin D[25(OH)D],macrophage inflammatory protein-1(MCP-1)and mild cognitive impairment(MCI)in patients with Hashimoto's thyroiditis(HT)with normal thyroid function,in order to provide auxiliary predictive indicators for the occurrence of MCI in HT patients with normal thyroid function.Methods:167 HT patients with normal thyroid function who were admitted to the Three Gorges Hospital affiliated to Chongqing University from January 2021 to May 2023 were selected as HT group,another 87 healthy volunteers who underwent physical examination during the same period were selected as control group,HT patients with normal thyroid function were divided into MCI group(n=71)and non-MCI group(n=96)according to whether the occurrence of MCI.Serum 25(OH)D and MCP-1 levels were detected by enzyme-linked immunosorbent assay.The factors affecting MCI in HT patients with normal thyroid function were analyzed by established multivariate Logistic regres-sion model,the predictive value of serum 25(OH)D and MCP-1 levels for MCI in HT patients with normal thyroid function were ana-lyzed by drawn receiver operating characteristic(ROC)curve.Results:Compared with control group,the serum 25(OH)D level in HT group was decreased,and the MCP-1 level was increased(P＜0.05).The incidence of MCI in 167 HT patients with normal thyroid func-tion was 42.51％(71/167).Multivariate Logistic regression analysis showed that,elevated thyroid peroxidase antibody(TPOAb)and ele-vated MCP-1 were independent risk factors for MCI in HT patients with normal thyroid function,and elevated 25(OH)D was an indepen-dent protective factor(P＜0.05).ROC curve analysis showed that,the area under the curve of serum 25(OH)D combined with MCP-1 in predicting MCI in HT patients with normal thyroid function was 0.892,which was greater than 0.785 and 0.770 predicted by serum 25(OH)D and MCP-1 alone.Conclusion:The decrease of serum 25(OH)D level and the increase of MCP-1 level in HT patients with nor-mal thyroid function are closely relate to the occurrence of MCI,the combination of serum 25(OH)D and MCP-1 has a higher value in predicting MCI in HT patients with normal thyroid function.
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