Clinical Study on Serum CysC,CT-1 Combined with FFR Value in Predicting the Risk of Major Adverse Cardiac Events after PCI in Patients with Coronary Heart Disease with Moderate Coronary Artery Stenosis
Objective:To investigate the predictive value of serum cystatin C(CysC),cardiotrophin-1(CT-1)combined with coro-nary fractional flow reserve(FFR)in predicting the risk of major adverse cardiac events(MACE)after percutaneous coronary interven-tion(PCI)in patients with coronary heart disease with moderate coronary artery stenosis.Methods:260 patients with coronary heart dis-ease with moderate coronary artery stenosis who were admitted to Nanjing Drum Tower Hospital from January 2020 to March 2022 were selected,patients were divided into MACE group(n=36)and non-MACE group(n=224)according to whether MACE occurred 1 year after PCI.Serum CysC and CT-1 levels were detected and FFR values were calculated.The risk factors affecting the occurrence of MACE after PCI in patients with coronary heart disease with moderate coronary artery stenosis were analyzed by constructed multivariate Logistic regression model,the predictive value of serum CysC,CT-1 combined with FFR value for the risk of MACE after PCI in patients with coronary heart disease with moderate coronary artery stenosis were analyzed by receiver operating characteristic(ROC)curve.Results:After 1 year of follow-up,there was no loss of follow-up,and the incidence of MACE after PCI in 260 patients with moderate coronary artery stenosis was 13.85％(36/260).Compared with non-MACE group,the levels of serum CysC and CT-1 in MACE group increased,and the FFR value decreased(P＜0.05).Multivariate Logistic regression analysis showed that,KILLIP grade ≥ Ⅲ,elevated CysC and ele-vated CT-1 were independent risk factors for MACE after PCI in patients with coronary heart disease with moderate coronary artery stenosis,and elevated left ventricular ejection fraction and elevated FFR were independent protective factors(P＜0.05).ROC curve analy-sis showed that,the area under the curve of serum CysC,CT-1 combined with FFR in predicting the risk of MACE after PCI in patients with moderate coronary artery stenosis was 0.906,which was greater than 0.771,0.775 and 0.797 predicted by serum CysC,CT-1 and FFR alone.Conclusion:The increase of serum CysC and CT-1 levels and the decrease of FFR value are closely relate to the occurrence of MACE after PCI in patients with moderate coronary artery stenosis,the value of serum CysC and CT-1 combine with FFR value in predicting the risk of MACE after PCI in patients with moderate coronary artery stenosis is higher.
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