Relationship between Real-Time Ultrasound Elastography Parameters,Serum CA153,IGF1 and HE4 Levels and Clinicopathological Features of Early Cervical Cancer and Analysis of Their Predictive Value
Objective:To explore the relationship between real-time ultrasound elastography parameters,serum carbohydrate anti-gen 153(CA153),insulin growth factor 1(IGF1),and human epididymal secreted protein 4(HE4)levels with clinicopathological fea-tures of early cervical cancer and their predictive value.Methods:85 patients with early cervical cancer admitted to our hospital from Jan-uary 2022 to June 2023 were selected as the cervical cancer group,and another 85 patients with cervical precancerous lesions admitted during the same period were selected as the cervical precancerous lesion group.Both groups underwent real-time ultrasound elastography and serum levels of CA153,IGF1,and HE4 were measured.Explored the relationship between real-time ultrasound imaging,serum CA153,IGF1,and HE4 levels and clinical pathological characteristics of cervical cancer patients.The diagnostic value of real-time ultra-sound elastography parameters,serum CA153,IGF1,and HE4 in early cervical cancer patients was analyzed using receiver operating characteristic(ROC).Results:Compared with the cervical precancerous lesion group,the elastic strain ratio and elastic image compres-sion index of the cervical cancer group were significantly increased(P＜0.05),and the serum levels of CA153,IGF1 and HE4 were signif-icantly increased(P＜0.05).The real-time ultrasound imaging parameters,serum CA153,IGF1 and HE4 levels in patients with FIGO Ⅱstage and low differentiation were significantly higher than those in patients with FIGO I stage and medium to high differentiation(P＜0.05).ROC curve showed that the area under the curve(AUC)of elastic strain ratio,elastic image compression index,CA1 53,IGF1 and HE4 in the diagnosis of early cervical cancer was 0.811,0.807,0.760,0.649 and 0.764,respectively,and the AUC of combined diagnosis was the largest,0.944.Conclusion:Real-time ultrasound elastography parameters,serum CA153,IGF1 and HE4 are related to the stage and differentiation of early cervical cancer,and have certain clinical value in the diagnosis of early cervical cancer,and the value of com-bined diagnosis is higher.
Real-time ultrasound elastographyCA153IGF1HE4Early cervical cancerDiagnostic value
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