Study on the Relationship between Serum Amyloid A,Cholinesterase,Apolipoprotein A1 Levels and Cognitive Function in Patients with Alzheimer's Disease
Objective:To investigate the relationship between serum amyloid A(SAA),cholinesterase(CHE),apolipoprotein A1(ApoA1)levels and cognitive function in patients with Alzheimer's disease(AD).Methods:103 AD patients who were treated in our hos-pital from December 2020 to May 2023 were selected as case group,and 80 healthy volunteers who underwent physical examination in our hospital during the same period were selected as control group.The levels of serum SAA,CHE and ApoA1 in two groups were de-tected by enzyme-linked immunosorbent assay.The cognitive function in two groups was evaluated by Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE).Serum SAA,CHE,ApoA1 levels and MMSE,MoCA scores were compared be-tween two groups.AD patients were divided into mild group,moderate group and severe group according to the MMSE score,the levels of serum SAA,CHE and ApoA1 in mild group,moderate group and severe group were observed and compared.The correlation between serum SAA,CHE,ApoA1 levels and MMSE score were analyzed by Pearson test.Results:The serum SAA in case group was higher than that in control group,and the serum CHE and ApoA1 levels were lower than those in control group(P＜0.05).The scores of MoCA and MMSE in case group were lower than those in control group(P＜0.05).The serum SAA levels in severe group and moderate group were higher than those in mild group,and severe group was higher than that of moderate group(P＜0.05).The levels of serum CHE and ApoA1 in severe group and moderate group were lower than those in mild group,and severe group was lower than that of moderate group(P＜0.05).Pearson test analysis showed that serum CHE,ApoA1 and MMSE scores were positively correlated,and serum SAA and MMSE scores were negatively correlated(P＜0.05).Conclusion:The abnormal increase of serum SAA and the abnormal decrease of serum CHE and ApoA1 levels in AD patients may be relate to the occurrence of cognitive dysfunction.
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