Study on the Efficacy and Mechanism of Furong Tongmai Capsule Combined with Liraglutide in the the Treatment of Type 2 Diabetes Patients with Macroangiopathy
Objective:To investigate the efficacy and mechanism of Furong Tongmai Capsules combined with liraglutide in treat-ment of type 2 diabetes patients with macroangiopathy.Methods:160 type 2 diabetes patients with macroangiopathy who were admitted toCangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province from January 2021 to December 2022 were selected,they were divided into group A(n=53,treated with conventional),group B(n=53,treated with conventional combined with liraglutide),and group C(n=54,treated with combined with Furong Tongmai capsule on the basis of group B)according to the ran-dom number method.The changes of carotid intima-media thickness(IMT),carotid atherosclerotic plaque area,glucose metabolism in-dexes,blood lipid indexes,serum homocysteine(Hcy),hypersensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)levels and the expression of key molecules of phosphoinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway were observed before and af-ter treatment in each group.Results:After treatment,the carotid IMT and carotid atherosclerotic plaque area in group C were significantly lower than those in group A and group B,and the carotid IMT and carotid atherosclerotic plaque area in group B were significantly lower than those in group A(P＜0.05).After treatment,the fasting plasma glucose(FPG),glycosylated hemoglobin A1c(HbA1c),2 h postpran-dial plasma glucose(2hPG),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),serum Hcy,hs-CRP,IL-6,PI3K messenger ribonucleic acid(mRNA),AKT mRNA levels in group C were significantly lower than those in group A and group B,and the high-density lipoprotein cholesterol(HDL-C)was significantly higher than that in group A and group B(P＜0.05).Conclusion:Furong Tongmai capsule combined with liraglutide is effective in the treatment of type 2 diabetes with macroangiopathy.It can effective-ly reduce blood glucose,regulate blood lipids,and exert anti-inflammatory effects.Its mechanism may be related to the regulation of PI3K/AKT signaling pathway.
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