Clinical Value of Contrast-Enhanced Ultrasound Parameters Combined with Serum AFP and DKK1 in the Differential Diagnosis of Primary Liver Cancer and Metastatic Liver Cancer
Objective:To explore the value of ultrasound contrast ultrasound parameters combined with serum alpha-fetoprotein(AFP)and secreted protein Dikkopf-1(DKK 1)to identify primary liver cancer(PLC)from metastatic liver cancer(MLC).Methods:92 PLC patients(PLC group)and 95 MLC patients(MLC group)who were admitted to our hospital from February 2020 to December 2022 were selected,all patients underwent contrast-enhanced ultrasound examination and serum AFP and DKK1 levels were detected.The value of contrast-enhanced ultrasound parameters combined with serum AFP and DKK1 in identifying PLC and MLC was analyzed by receiver operating characteristic(ROC).Results:Initiation time,Enhancement rate and 50％tilt rate in PLC group were lower than those in MLC group(P＜0.05),and the peak time,Strengthing strength,serum AFP and DKK1 levels were higher than those in MLC group(P＜0.05).The area under the curve of initiation time,Enhancement rate,50％tilt rate,peak time,Strengthing strength,AFP and DKK1 in differential diagnosis of PLC and MLC was 0.725,0.655,0.716,0.697,0.761,0.695 and 0.754 respectively,and the area under the curve identifying PLC from MLC was 0.882,higher than the identification alone.Conclusion:The combination of Ultrasound contrast parame-ters and serum AFP and DKK1 has high efficiency in the identification of PLC and MLC,better than imaging alone or serum index iden-tification.
Primary liver cancerMetastatic liver cancerContrast-enhanced ultrasoundAlpha-fetoproteinSecreted protein dikkopf-1
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