Clinical Study of Systemic Immune Inflammatory Index Combined with Serum CXCL5 and CXCL12 in Predicting Recurrence in Patients with High Grade Glioma after Operation
Objective:To investigate the value of systemic immune inflammatory index(SII)combine with serum CXC chemokine ligand 5(CXCL5)and chemokine ligand 12(CXCL12)in predicting recurrence in patients with high grade glioma(HGG)after operation.Methods:169 patients with HGG who were underwent operation treatment in our hospital from January 2019 to January 2022 were selected.Neutrophil,lymphocyte,platelet count and serum CXCL5,CXCL12 levels were detected in patients with HGG,and SII was calculated before operation.Patients were followed up 1 year,patients with HGG were divided into recurrence group(113 cases)and non recurrence group(56 cases)according to the recurrence after operation.The influencing factors of recurrence in patients with HGG after operation were analyzed by multivariate Logistic regression analysis.The value of SII combine with serum CXCL5 and CXCL12 in predicting recurrence in patients with HGG after operation were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of SII and serum CXCL5 and CXCL12 in recurrent group were higher than those in non recurrent group(P＜0.05).The recurrence of patients with HGG after operation was related to age,KPS score before operation,WHO pathological grade,surgical resection range and after operation treatment(P＜0.05),and not to gender(P＞0.05).Multivariate logistic analysis showed that,WHO pathological gradeⅣ,surgical resection range were incomplete resection,elevated SII,elevated serum CXCL5,and elevated CXCL12 were risk factors for recurrence in patients with HGG after operation(P＜0.05).The area under the curve of SII,serum CXCL5 and CXCL12 alone in predict-ing recurrence of patients with HGG after operation was 0.820,0.875 and 0.845,respectively,the area under the curve of combined de-tection was 0.964,which was higher than that of single index detection.Conclusion:Elevate SII,elevate serum CXCL5,and elevate CXCL12 in recurrence patients with HGG after operation,and WHO pathological grade Ⅳ,surgical resection range were incomplete resection are risk factor in recurrence patients with HGG after operation.Combine detection of SII,serum CXCL5,and CXCL12 has a high predictive value for recurrence in patients with HGG after operation.
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