Study on the Relationship between the Expression of BCLAF1 and SETDB1 in Hepatitis B-Related Hepatocellular Carcinoma and Clinicopathological Features and Prognosis after Operation
Objective:To investigate the relationship between the expression of Bcl-2-related transcription factor-1(BCLAF1)and histone methylase SET domain branch type 1(SETDB1)in hepatitis B-related hepatocellular carcinoma and clinicopathological features and prognosis after operation.Methods:127 patients with hepatitis B-related hepatocellular carcinoma underwent radical resection in Zhujiang Hospital of Southern Medical University and Gaozhou People's Hospital from January 2018 to June 2020 were selected,the resected cancer tissues and adjacent tissues were taken,and the expression of BCLAF1 and SETDB1 were detected by immunohistochemistry,the relationship between the expression of BCLAF1 and SETDB1 and clinicopathological features were analyzed.3 years after follow up,the survival differences of patients with different expressions of BCLAF1 and SETDB1 were analyzed by Kaplan-Meier survival curve,the factors affecting the prognosis of patients with hepatitis B-related hepatocellular carcinoma were analyzed by multivariate Cox regression analysis.Results:The positive expression rates of BCLAF1 and SETDB1 in cancer tissues were higher than those in adjacent tissues(P＜0.05).The positive expression rates of BCLAF1 and SETDB1 in cancer tissues of patients with poor differentiation,TNM stage Ⅲa,portal vein invasion and lymph node metastasis were higher than those in cancer tissues of patients with moderate to high differentiation,TNM stage Ⅰ～Ⅱ,no portal vein invasion and no lymph node metastasis(P＜0.05).The 3-year overall survival(OS)rate in HBV-related HCC patients with BCLAF1 positive expression and SETDB1 positive expression were lower than those in HBV-related HCC patients with BCLAF1 negative expression and SETDB1 negative expression(P＜0.05).Multivariate Cox regression analysis showed that lymph node metastasis,BCLAF1 positive expression and SETDB1 positive expression were risk factors for poor prognosis in patients with hepatitis B-related hepatocellular carcinoma(P＜0.05).Conclusion:The positive expression rates of BCLAF1 and SETDB1 in hepatitis B-related hepatocellular carcinoma tissues are increase,the positive expression of BCLAF1 and SETDB1 are relate to poor differentiation,TNM stage,portal vein invasion,lymph node metastasis and poor prognosis.
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