Effect of Tongyuan Acupuncture Method on Serum Neurotrophic Factors and Hypothalamic-Pituitary-Adrenal Axis Function in Patients with Post Stroke Depression of Liver Qi Stagnation Type
Objective:To observe the effect of Tongyuan acupuncture method on serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function in patients with post stroke depression(PSD)of liver qi stagnation type.Methods:According to the random number table method,102 PSD patients admitted to Foshan Hospital of Traditional Chinese Medicine from September 2021 to November 2022 were divided into a control group(n=51,receiving routine treatment)and an observation group(n=receiving Tongyuan acupuncture on the basis of the control group).The efficacy,depression and changes of serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function indexes were compared between two groups.Results:Compared with control group,the total clinical effective rate in observation group was higher(P＜0.05).Compared with control group 4 weeks after treatment and 8 weeks after treatment,the Hamilton Depression Scale 24 item version(HAMD-24)score in observation group was lower(P＜0.05).Compared with control group 8 weeks after treatment,the serum nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)and insulin-like growth factor-1(IGF-1)in observation group were higher,and the plasma adrenocorticotropic hormone(ACTH),cortisol(Cor)and corticotropin releasing hormone(CRH)were lower(P＜0.05).Conclusion:PSD patients of liver qi stagnation type are treat with Tongyuan acupuncture method,the depressive symptoms can be significantly alleviate,the serum neurotrophic factors can be regulate,and the function of hypothalamus-pituitary-adrenal axis can be improve,which has high application value.
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