Analysis of the Diagnostic Value and Prognostic Value of Dynamic Contrast Enhanced MRI Quantitative Parameters Combined with CA15-3 and Peripheral Blood CTC in Breast Cancer
Objective:To investigate the value of dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)quantita-tive parameters combined with carbohydrate antigen 15-3(CA15-3)and peripheral blood circulating tumor cells(CTC)in the diagnosis and prognosis of breast cancer.Methods:95 breast cancer patients(malignant group)and 101 benign breast lesions patients(benign group)who were admitted to our hospital from January 2018 to January 2020 were selected.All patients underwent DCE-MRI examina-tion and serum CA15-3 and peripheral blood CTC detection,breast cancer patients were followed up for 3 years,patients were divided into death group and survival group according to the survival situation.The value of DCE-MRI parameters combined with CA15-3 and CTC in the diagnosis and prognosis of breast cancer were analyzed by receiver operating characteristic(ROC)curve.Results:The rate constant(Kep),volume transfer constant(Ktrans),extravascular extracellular volume fraction(Ve),serum CA15-3 and peripheral blood CTC in malignant group were higher than those in benign group(P＜0.05).During the follow-up period,2 cases were lost to follow-up,45 cases died and 48 cases survived,Kep,Ktrans,Ve,serum CA15-3 and peripheral blood CTC in death group were higher than those in survival group(P＜0.05).The area under the curve of combined Kep,Ktrans,Ve,serum CA15-3 and peripheral blood CTC in the diagno-sis of breast cancer and the prediction of breast cancer prognosis was 0.865 and 0.908 respectively,which were higher than those of sin-gle diagnosis and prediction.Conclusion:The values of DCE-MRI parameters Kep,Ktrans,Ve,serum CA15-3 and peripheral blood CTC levels are increase in breast cancer patients,the combination of DCE-MRI parameters,serum CA15-3 and peripheral blood CTC can improve the diagnosis and prognosis of breast cancer.
Breast cancerDynamic contrast enhanced magnetic resonance imagingCarbohydrate antigen 15-3Circulating tumor cellsDiagnosisPrognosis
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