Diagnostic Value of Ultrasonic Shear Wave Elastography Combined with Serum Adiponectin and Urokinase Plasminogen Activator in Benign and Malignant Thyroid Nodules
Objective:To investigate the value of ultrasonic shear wave elastography(SWE)combined with serum adiponectin(AFN)and urokinase plasminogen activator(uPA)in differentiating benign and malignant thyroid nodules.Methods:127 patients with thyroid nodules who underwent surgical thyroidectomy were selected in our hospital from January 2020 to December 2022.All patients underwent SWE examination before surgery,serum AFN and uPA levels were detected,and postoperative pathological results were recorded.According to the postoperative pathological results,the patients were divided into malignant group and benign group.Analyzed the value of SWE parameters combined with serum AFN and uPA in differentiating benign and malignant thyroid nodules.Results:There were 21 cases of malignant nodules(malignant group)and 106 cases ofbenign nodules(benign group).In the malignant group,the serum uPA level was higher than that in the benign group(P＜0.05),and the serum AFN level was lower than that in the benign group(P＜0.05).The area under the curve of Max,Mean,Min,AFN and uPA were 0.609,0.754,0.600,0.777 and 0.701,respectively,and the area under the curve of combined Max,Mean,Min,AFN and uPA was 0.935,higher than each indicator to identify separately.Conclusion:In patients with malignant thyroid nodules,SWE parameters Max,Mean,Min and serum uPA levels increased,while AFN levels decreased.Combining SWE parameters with serum AFN and uPA can improve the differential efficacy of thyroid nodules.
Ultrasonic shear wave elastic imagingAdiponectinUrokinase plasminogen activatorThyroid noduleIdentify value
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